Evaluation of the relationship between metabolic-associated fatty liver disease and sarcopenic obesity in patients with diabetes

Elena Makhlina; Yana Navmenova; Tatyana Mokhort

doi:10.1530/endoabs.110.P796

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Endocrine Abstracts (2025) 110 P796 | DOI: 10.1530/endoabs.110.P796

ECEESPE2025 Poster Presentations Multisystem Endocrine Disorders (43 abstracts)

Evaluation of the relationship between metabolic-associated fatty liver disease and sarcopenic obesity in patients with diabetes

Elena Makhlina ¹ , Yana Navmenova ² & Tatyana Mokhort ³

Author affiliations

¹«Gomel State Medical University», Department of Internal Medicine No. 1 with courses in endocrinology and hematology, Gomel, Belarus; ²«Republican research center for radiation medicine and human ecology», Endocrinology, Gomel, Belarus; ³Belarusian State Medical University, Endocrinology, Minsk, Belarus

JOINT605

Objective: To assess the relationship between metabolic-associated fatty liver disease (MAFLD) in patients with diabetes and sarcopenic obesity (SO) indices.

Materials and Methods: The study included 92 patients with diabetes (45 men and 47 women). The average age of patients was 55.90±14.18 years and duration of diabetes was 16.80±9.34 years. Muscle strength (MS) was assessed using hand dynamometry measuring arm strength. Muscle function (MF) was assessed using the 4-meter walking speed test. Muscle mass (MM) and fat mass (FM) were assessed using dual-energy X-ray absorptiometry (DXA) ("lunAR prodigy") as the ratio of appendicular muscle mass (AMM) to height (AMM/m²), AMM to weight (AMM/weight), FM to height (FM/m²). The body mass index (BMI), waist circumference (WC), and glycated hemoglobin (HbA1c) were determined. The presence of MAFLD was determined based on the results of ultrasound examination of the liver and calculated diagnostic indices (ST-index, FLI). Statistical processing was performed using the statistical program «Statistica 10.0».

Results: In patients with diabetes, 86% of cases taking into account the ST- index and 96% of cases taking into account the FLI were found to have SO. FLI is positively associated with the age of patients (r_s = 0.46; p < 0.05), BMI (r_s= 0.92; p < 0.05), WC (r_s= 0.90; p < 0.05), FM/m2 (r_s = 0.69; p < 0.05), AMM/m2 (r_s = 0.46; p < 0.05) and negatively associated with MS (r_s = - 0.34; p < 0.05), MF (r_s = - 0.32; p < 0.05), AMM/weight (r_s = - 0.64; p < 0.05). ST- index is positively correlated with patients’ age (r_s = 0.68; p < 0.05), BMI (r_s = 0.88; p < 0.05), WC (r_s = 0.92; p < 0.05), FM/m² (r_s = 0.70; p < 0.05), AMM/m² (r_s= 0.34; p < 0.05) and negatively correlated with MS (rs = - 0.33; p < 0.05), MF (r_s = - 0.45; p < 0.05), AMM/weight (r_s = -0.62; p < 0.05). FLI and ST-index are not correlated with the duration of diabetes and the level of Hb1c (p> 0.05).

Conclusion: In patients with MAFLD and diabetes, 86% to 96% of cases show SO associated with the patient’s age and independent of the duration of diabetes and the Hb1c level. MAFLD in diabete is associated with a change in body composition due to a decrease in MM and an increase in FM, the degree of decrease in MS and MF.