Laterality of amygdalavolume of brain in different genders help predict individuals with ambiguous genitalia of disorders of sexual development

Yan Li; Ting Dong; Chunjie Liu; Shaolian Zang; Xiaoqin Yin; Shasha Zhou; Sheng Guo; Zhi Yang; Pin Li

doi:10.1530/endoabs.110.P848

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Endocrine Abstracts (2025) 110 P848 | DOI: 10.1530/endoabs.110.P848

ECEESPE2025 Poster Presentations Pituitary, Neuroendocrinology and Puberty (162 abstracts)

Laterality of amygdalavolume of brain in different genders help predict individuals with ambiguous genitalia of disorders of sexual development

Yan Li ¹ , Ting Dong ¹ , Chunjie Liu ¹ , Shaolian Zang ¹ , Xiaoqin Yin ¹ , Shasha Zhou ¹ , Sheng Guo ¹ , Zhi Yang ² & Pin Li ¹

Author affiliations

¹Department of Endocrinology, Children’s Hospital of Shanghai, School of Medicine, Shanghai Jiaotong University, Shanghai, China; ²Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China

JOINT4025

Background: Human sex characteristics include genetic, anatomical structure, physiological function, neuropsychology and social identity. Patients who were born with ambiguous genitalia are in intersex conditions. Sex decisions of raising at their early years are significant and difficult. Hormones, chromosomes, and clinical phenotypes of genitalia are the major influences leading to decisions of sex, and they also guide sex differences in brain development. Individuals of 21-hydroxylase deficiency (21OHD) with chromosome of 46,XX offer a unique opportunity to address these issues. They have a 46,XX chromosome, high testorstorone and ambiguous genitalia of clitoridauxe.

Objective: Toexamine the asymmetry of the different zones volume of subcortical brain in normal girls and boys, build a classifier to predict the cases’ sex and compare with their psychological sex.

Methods: 11 children of CAH with 46,XX, 123 boys and 124 girls were included. T1-weighted anatomical data were collected using a magnetization-prepared rapid acquisition gradient-echo sequence. Pre-school activities investory (PSAI) was used to assessed the psychological sex in individuals below 5 years old, and children’s sex role inventory (CSRI) was used in cases of and older than 5 years old.

Results: We found that laterality of Amygdala volume was significatly different between genders, showing a significant larger laterality of Amygdala volume in boys than that of girls (T=2.335280, p=0.021). Based on the laterality, we built a classifier to vertify the brain sex of the 11 cases. The brain sex of all the cases was identical with their psychological sex assessed by the questionnaries.

Conclusions: The findings further revealed the gender differences in brain, and we do use diversified ways to predict gender of individuals of disorders of sexual development (DSD). It is equally important to raise gender in accordance with neuropsychological needs and to obtain social acceptance as to maintain a status consistent with genetic, anatomical, and endocrine physiological functions.