ECEESPE2025 Poster Presentations Pituitary, Neuroendocrinology and Puberty (162 abstracts)
Clinical presentation and outcomes of pituitary apoplexy in patients with PitNETs: an Italian multicentric study
Maria Francesca Birtolo 1,2 , Federico Gatto 3 , Carolina Di Somma 4 , Filippo Ceccato 5 , Silvia Grottoli 6 , Salvatore Cannavò 7 , Roberto Baldelli 8 , Maria Rosaria Ambrosio 9 , Antonio Bianchi 10 , Giovanna Mantovani 11 , Gherardo Mazziotti 1,2 & Andrea Lania 1,2
1Humanitas University, Department of Biomedical Sciences, Milan, Italy; 2IRCCS Humanits Research Hospital, Endocrinology, Diabetology and Medical Andrology Unit, Milan, Italy; 3IRCCS Ospedale Policlinico San Martino, Endocrinology Unit, Genova, Italy; 4Federico II University, Department of Molecular and Clinical Endocrinology, Napoli, Italy; 5University-Hospital of Padova, Endocrine Disease Unit, Padova, Italy; 6University of Turin, Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, Turin, Italy; 7University of Messina, Endocrinology Unit, Department of Human Pathology of Adulthood and Childhood DETEV, Messina, Italy; 8A.O. San Camillo-Forlanini, Endocrinology Unit, Department of Oncology and Medical Specialities, Rome, Italy; 9University Hospital of Ferrara, Unit of Endocrinology and Metabolic Diseases, Department of Specialty Medicines, Ferrara, Italy; 10Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC Endocrinology and Diabetology, Rome, Italy; 11Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Endocrinology Unit, Milan, Italy
JOINT3588
Purpose: To assess the clinical presentation and outcomes of pituitary apoplexy in a large cohort of patients with PitNETs.
Methods: Retrospective multicenter study, including 162 patients (100 males, median age 51 years) from ten Italian referral centers for PitNETs. All patients >18 years old with a diagnosis of pituitary apoplexy based on clinical and radiological features were eligible. Clinical and biochemical assessment was performed at the time of apoplexy and after at least 12 months of follow-up.
Results: At the time of apoplexy, patients with macroadenomas had a higher frequency of headache (81.7% vs 45.5%, P = 0.011), visual field defects (57.7% vs 18.2%, P = 0.012), diplopia (39.4% vs 9.1%, P = 0.039) and hypopituitarism (64.8% vs 27.3%, P = 0.017) compared to those with microadenomas. Men were more likely to have secondary adrenal insufficiency (59.6% vs. 40.3%; P = 0.017) and central hypogonadism (61.2% vs. 36.1%, P = 0.002) and were more likely to undergo surgery (78.0% vs. 58.1%, P = 0.007) compared to women. In terms of outcomes, no differences were observed between patients who underwent surgery and those who did not, except for hypothyroidism, which was more prevalent in surgically treated patients (62.8% vs 45.8%, P = 0.034). Nevertheless, 67.7% of the surgically treated patients (48 out of 71) had a pre-existing diagnosis of central hypothyroidism at the time of apoplexy.
Conclusion: The size of the adenoma and the male se, have been demonstrated to influence the clinical presentation of the apoplectic event, while the management, surgical or conservative, does not appear to affect the long-term outcomes.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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