ECEESPE2025 Poster Presentations Pituitary, Neuroendocrinology and Puberty (162 abstracts)
Clinical, metabolic, bone and body composition characteristics of patients with various causes of childhood growth hormone deficiency (COGHD) in the transition period - a single center study
Mirjana Doknic 1,2 , Marko Stojanovic 1,2 , Tatjana Milenkovic 3 , Slađana Todorović 3 , Vera Zdravkovic 2,4 , Maja Jesic 2,4 , Mihajlo Curcic 2 , Sandra Pekic Djurdjevic 1,2 , Dragana Miljic 1,2 , Marina Nikolic Djurovic 1,2 , Ivana Cekic 1 , Ivan Jevtic 1 , Zvezdana Jemuovic 1 & Ivan Soldatovic 2,5
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Neuroendocrine Department, Belgrade, Serbia; 2Medical Faculty, University of Belgrade, Belgrade, Serbia; 3Mother and Child Health Care Institute of Serbia “Dr Vukan Cupic“, Belgrade, Serbia; 4University Children’s Clinic, Belgrade, Serbia; 5Institute of Medical Statistics and Informatics, Belgrade, Serbia
JOINT1126
Introduction: Patients with COGHD represent a heterogeneous group in many respects, and one of the most important points is the etiology of this hormone deficiency. In this regard, reported studies are inconsistent in relation to anthropometric characteristics, metabolic profile, body composition (BC) and bone mineral density (BMD) of these subjects.
Aim: To investigate the influence of the etiology of COGHD on the clinical characteristics of patients after completion of growth in transition period.
Patients and Methods: In a monocentric, observational, retrospective cross-sectional study spanning the last 20 years, we investigated 302 COGHD patients (16-25 years old, mean age 18.8 ±2.1 years, 198 males) at first evaluation after transfer from pediatrics to the adult department. Sixty-two subjects experienced childhood-onset endocranial tumor (TUM, 22.5%). Other patients had congenital (CON, 59.2%) or idiopathic COGHD (IDI 18.3%). Cross-sectional analyisis of metabolic parameters, BC and BMD were performed in these patients.
Results: Persistent GHD was confirmed in 67% of patients after retesting at adult department. The three observed etiological groups did not differ according to body weight, body height, BMI and waist/hip ratio (P > 0.05). Insulin levels in the OGTT were significantly higher in the TUM group, than in IDI and CON patients, observing basal insulin, AUC (area under the curve) and peak insulin (p<0.01). TUM group showed significantly higher HbA1c levels, total cholesterol, LDL cholesterol and triglycerides compared to the two other groups (p< 0.001). BMD (g/cm2) and Z score at spine was significantly lower in TUM patients compared to CON and IDI groups. Lean body mass did not differ between 3 investigated groups (P >0.05), while fat mass and percentage of fat were higher in TUM group (p< 0.01).
Conclusion: the cause of COGHD proved to be an extremely important parameter in metabolic characteristics, body composition and bone mass in the transition period. We have shown that tumor-induced GHD in childhood is a risk factor for increased insulin resistance, unfavorable lipid profile and body composition, with susceptibility to lower bone density and thus the risk of bone fractures.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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