ECEESPE2025 Poster Presentations Pituitary, Neuroendocrinology and Puberty (162 abstracts)
Exosomal miRNA expression profiles and pathway enrichment analysis in girls with central precocious puberty and premature thelarche
Hye Jin Lee 1,2 , Eu Seon Noh 3 , Yena Lee 1 , Hye Young Jin 4 , Young Jun Seo 5 , Young Suk Shim 6 , Hwalrim Jeong 7 & Il Tae Hwang 3
1Hallym University Sacred Heart Hospital, Pediatrics, Anyang, South Korea; 2Hallym University Kangman Sacred Heart Hospital, Seoul, South Korea; 3Kangdong Sacred Heart Hospital, Seoul, South Korea; 4Kangdong Sacred Heart Hospital, Pediatrics, Seoul, South Korea; 5Hallym University Chuncheon Sacred Heart Hospital, Pediatrics, Chuncheon, South Korea; 6Ajou University Hospital, Pediatrics, Suwon, South Korea; 7Soonchunhyang University Cheonan Hospital, Pediatrics, Cheonan, South Korea
JOINT1131
Context: Central precocious puberty (CPP) is rapidly increasing in prevalence among girls, with most cases being idiopathic. Exaggerated thelarche (ET) and premature thelarche (PT) are variants of early puberty that can be difficult to distinguish from CPP in initial clinical evaluations. Exosomal microRNAs are stable biomarkers capable of crossing the blood-brain barrier. However, human studies on miRNAs in CPP and related conditions remain limited.
Objective: To identify distinct exosomal miRNA profiles in girls with CPP, ET, and PT, and explore the target genes and pathways involved in pubertal development.
Methods: This cross-sectional study included 27 girls aged 6-8 years, categorized into CPP, ET, PT, and control groups. Serum exosomal miRNAs were sequenced, differentially expressed miRNAs (DEmiRNAs) were analyzed, target genes were predicted, and pathway enrichment analysis was performed.
Results: Distinct exosomal miRNA patterns were observed among CPP, ET, and control groups, identifying 307 DEmiRNAs. The PT group showed a distinct miRNA expression from the control group but not show clear separation from the CPP or ET groups. Enriched pathways included AGE-RAGE, MAPK, and mTOR signaling, with group-specific enrichment observed in Hippo and neurotrophin signaling pathways.
Conclusions: This study identifies distinct serum exosomal miRNA patterns in CPP, ET, and PT groups. The enrichment of the AGE-RAGE pathway suggests a potential link to dietary habits. Serum exosomal miRNAs may serve as biomarkers or therapeutic targets, providing insights into environmental factors influencing early puberty.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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