ECEESPE2025 Poster Presentations Pituitary, Neuroendocrinology and Puberty (162 abstracts)
Sellar and parasellar lesions in the childhood, adolescence and transition age
Sandra Pekic Djurdjevic 1,2 , Mirjana Doknic 1,2 , Dragana Miljic 1,2 , Marko Stojanovic 1,2 , Tatjana Milenkovic 3 , Rade Vukovic 1,3 , Katarina Mitrović 1,3 , Slađana Todorović 3 , Sanja Panic Zaric 3 , Vera Zdravkovic 1,4 , Maja Jesic 1,4 , Emilija Manojlovic Gacic 1,5 , Mihailo Milicevic 1,6 , Aleksandar Stanimirovic 1,6 , Vuk Scepanovic 1,6 , Zvezdana Jemuovic 2 , Ivana Cekic 2 , Ivan Jevtic 2 , Marina Nikolic Djurovic 1,2 & Vera Popovic 1
1Medical Faculty, University of Belgrade, Belgrade, Serbia; 2Clinic for Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center of Serbia, Department of Neuroendocrinology, Belgrade, Serbia; 3Mother and Child Health Care Institute of Serbia “Dr Vukan Cupic“, Belgrade, Serbia; 4University Children’s Clinic, Belgrade, Serbia; 5Institute of Pathology, Belgrade, Serbia; 6Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
JOINT1751
Background: Recognizing sellar and parasellar lesions (S&PL) during childhood, adolescence, and transition age can be challenging and is often delayed due to the rarity of these diseases.
Objective: To investigate the clinical characteristics and types of pediatric S&PL:pituitary adenomas (PAs), and nonpituitary lesions (neoplastic, inflammatory).
Methods: A total of 195 patients (11.7%) with PAs diagnosed before the age of 25 were identified from the Department of Neuroendocrinologýs PA database (n = 1668) spanning the past 20 years and compared with 47 pediatric patients with nonpituitary S&PL. We analysed gender, age at diagnosis, size and type of S&PL.
Results: A total of 242 patients S&PL were included in the study (189 females,78.1%), with a mean age of 19.6±0.3years (range,3-25). Among these,195 patients had PA, with a mean age of 20.5±0.2years (range,10-25;161 females,82.6%). Of the PA patients,56 (28.7%) were younger than 18 years at the time of diagnosis. Functional PAs were significantly more common (n = 151;77.4%) compared to non-functioning PAs (n = 44;22.6%). Prolactinomas were the most prevalent type of functional PAs (n = 133;68.2%), with 89 microadenomas (86 in females). Thirteen patients (6.2%) had somatotropinomas, most of which were macroadenomas (n = 12), with male predominance (n = 9). Five patients (2.6%) had corticotropinomas, including three microadenomas (2 in males). Non-functioning PAs accounted for 44 cases (22.6%), with 18 microadenomas (17 in females). Patients with corticotropinomas were younger than those with prolactinomas or non-functioning PAs (17.4±1.4 vs. 20.6±3.2 and 20.4±3.3years, respectively; P < 0.05). Microadenomas (n = 111;56.9%) were significantly more prevalent than macroadenomas (n = 63;32.3%;P < 0.05;tumor size unknown in 21). In conrast,47 patients with nonpituitary S&PL were significantly younger than the PA group (mean age:16.1±0.9 vs. 20.5±0.2years,P < 0.001) and exhibited a male predominance (n = 28,59.6%). Craniopharyngiomas were the most common type of nonpituitary lesion (n = 22,46.8%), followed by germinomas (n = 10,21.3%). Other neoplastic lesions included three xanthogranulomas, one chordoma, one glioma and one granulosa cell tumor (n = 6,12.8%). Additionally, histiocytosis X was identified in five patients (10.6%) and hypophysitis was diagnosed in four (8.5%). Among patients with nonpituitary lesions, almost all (n = 42,89.4%) underwent surgery, and 22 patients (46.8%) received radiation therapy. Hypopituitarism was common in this group, with 39 patients (83%) diagnosed with multiple pituitary hormone deficiencies (PHD), five (10.6%) with isolated PHD, and 15 (31.9%) with ADH deficiency. Only three patients maintained normal pituitary function (6.4%).
Conclusion: Sellar and parasellar lesions in pediatric patients are rare. Among PAs, functioning tumors, particularly microprolactinomas, are the most common phenotype, with a notable female predominance. Microadenomas are uncommon in adolescent males. Somatotropinomas are predominantly macroadenomas with a male predominance, contrary to corticotropinomas (microadenoma, no sex difference). Patients with nonpituitary S&PL tends to be younger, predominantly male, and more frequently present with hypopituitarism and ADH deficiency compared to those with PAs. Managing these pediatric patients is particularly challenging due to the risk of late-onset complications (endocrine, metabolic, bone, and cardiovascular disorders).
Volume 110
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more