ECEESPE2025 Poster Presentations Reproductive and Developmental Endocrinology (93 abstracts)
Remission of polycystic ovary syndrome based on the recovery of ovarian morphology identified by three-dimensional power doppler ultrasonography:a retrospective cohort study
Keying Su 1 , Meili Cai 2 , Chang Liu 3 , Diliqingna Dilimulati 2 , Yuqin Zhang 2 , Jiayi Lu 1 , Xiaowen Shao 4 , Shen Qu 2 & Manna Zhang 5
1Department of clinical laboratory medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China, Shanghai, China; 2Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China, Shanghai, China; 3Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China, Shanghai, China; 4Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China, Shanghai, China; 5Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China, Department of General Practice, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200331, People’s Republic of China, Shanghai, China
JOINT2897
Objective: Polycystic ovary syndrome (PCOS) is a high prevalence chronic disease. Limited studies have explored the issue of remission PCOS indicated by regular menstrual cycles or natural pregnancies. As 90% of women with PCOS showed polycystic ovary morphology (PCOM) on ultrasound examination, the aim of this study was investigated the rate of achieving remission of in patients with PCOS, which was based on the recovery of ovarian morphology in PCOS patients using three-dimensional (3D) ultrasound techniques after pharmacological approaches.
Methods: This retrospective study included 727 reproductive-aged women with PCOS recruited in the PCOS-specialized outpatient clinics at Shanghai Tenth People’s Hospital from May 2020 to August 2024. Since the initiation of medication, anthropometric parameters, biochemical variables, reproductive indicators at baseline and post-treatment period were collected at every three months. During the follow-up period, 3D ultrasonography was used to assess the presence of polycystic morphology.
Results: A total of 296 participants were eligible for the study, and 28 participants (9.46%) achieved remission of PCOS with regularized menstrual cycle, normalized ovarian morphology. The mean time to achieve remission of PCOS was 14.1±13.2 months. The remission group had significantly higher waist circumference (WC), waist-to-hip ratio (WHR), and higher follicle number in both ovaries than the non-remission group (P < 0.05) at baseline. In the remission group, significant reductions were observed post-treatment in body mass index (BMI), waist circumference, alanine aminotransferase (ALT), aspartate aminotransferase (AST), low-density lipoprotein cholesterol (LDL), progesterone, and total testosterone (TT). Meanwhile, there was a significant reduction in ovarian volume and follicle numbers of both ovaries in the patients with PCOS remission. Medication promoting insulin resistance and weight-loss (GLP-1 agonists, metformin, SGLT-2 inhibitors) were widely taken in the remission group.
Conclusion: Our study demonstrated that 9.46% patients with PCOS could achieve remission of PCOS with normalized ovarian morphology after taking medications for improving metabolism and weight loss.
Keywords: polycystic ovary syndrome, remission, three-dimensional power doppler ultrasonography.
Volume 110
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more