Late bedtime was associated with increased androgen and reduced lean mass in women with polycystic ovary syndrome: a cross-sectional study

Yuqin Zhang; Min Zhang; Meili Cai; Xiaowen Shao; Diliqingna Dilimulati; Jiayi Lu; Cuiling Zhu; Haibing Chen; Changbin Li; Shen Qu; Manna Zhang

doi:10.1530/endoabs.110.P1055

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Endocrine Abstracts (2025) 110 P1055 | DOI: 10.1530/endoabs.110.P1055

ECEESPE2025 Poster Presentations Reproductive and Developmental Endocrinology (93 abstracts)

Late bedtime was associated with increased androgen and reduced lean mass in women with polycystic ovary syndrome: a cross-sectional study

Yuqin Zhang ¹ , Min Zhang ¹ , Meili Cai ¹ , Xiaowen Shao ² , Diliqingna Dilimulati ¹ , Jiayi Lu ³ , Cuiling Zhu ¹ , Haibing Chen ¹ , Changbin Li ⁴ , Shen Qu ¹ & Manna Zhang ^1,4

Author affiliations

¹Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; ²Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; ³Department of Clinical Laboratory, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; ⁴Department of General Practice, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

JOINT1243

Background: Despite limited evidence regarding the effect of bedtime on androgen and lean muscle mass, it is widely recognized as being associated with various metabolic diseases. The present study aimed to investigated the relationship between bedtime, androgen-associated traits, and dual-energy x-ray absorptiometry (DEXA)-based lean mass (LM) in polycystic ovary syndrome (PCOS).

Methods: This cross-sectional study recruited 899 reproductive-aged women with PCOS in the PCOS subspecialty clinic at Shanghai Tenth People’s Hospital, and finally 636 women entered the study. Anthropometric, metabolic, sex and reproductive hormonal characteristics, and body fat and lean composition measured by DEXA were collected. The information on bedtime was adapted from the Pittsburgh Sleep Quality Index and bedtime was categorized into three aspects: early bedtime (≤23:00), intermediate bedtime (>23:00 to 24:00), and late bedtime (>24:00) according to the time of falling asleep.

Results: There was 24.4% of participants fell asleep before 23:00, and 75.6% fell asleep after 23:00. After adjusting for age in covariance analysis, participants in both intermediate and late bedtime groups had fewer menstrual cycles and higher levels of anti-mullerian hormone (AMH) than those in the early bedtime group. Compared with early and intermediate bedtime, those with late bedtime had higher levels of total testosterone (TT) and androstenedione (AD). After controlling possible confounders, multiple liner regression analysis found that compared with early bedtime, late bedtime was independently associated with higher levels of TT and AD, meanwhile intermediate bedtime was independently associated with higher levels of AMH. Furthermore, late bedtime was independently correlated to reduced levels of muscle mass index LM/height² and appendicular muscle mass index appLM/height² compared with early bedtime.

Conclusion: This study provides novel insight that late bedtime (after 24:00) was independently related to elevated androgenic hormones and reduced LM in individuals with PCOS.

Keywords: polycystic ovary syndrome, sleep, bedtime, lean mass, androgen.