ECEESPE2025 Poster Presentations Reproductive and Developmental Endocrinology (93 abstracts)
Characterisation and evaluation of models of care for polycystic ovary syndrome (PCOS): a multinational study on clinical features, screening practices, and treatment outcomes
Aspasia Manta 1 , Anisah Ali 2 , Harshal Deshmukh 3 , Alexander Wilde 4 , Angharad James 4 , Raghavendar Palani 5 , Isin Yesilkaya Baylan 6 , Erkut Attar 6 , Kyranna Lafara 7 , Dimitrios Goulis 7 , Madhavi Gudipati 4 , Punith Kempegowda 8 & Devi Collaborative 9
1Attikon University Hospital, Athens, Greece; 2Birmingham Medical School, University of Birmingham, Birmingham, United Kingdom; 3Hull University Teaching Hospital NHS Trust, Hull, United Kingdom; 4South Tyneside and Sunderland NHS Foundation Trust, South Tyneside, United Kingdom; 5Royal Free Hospital NHS Foundation Trust, London, United Kingdom; 6PCOS and Hirsutism Clinic, Yeditepe University Hospital, Istanbul, Türkiye; 7Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece; 8Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom; 9University of Birmingham, Birmingham, United Kingdom
JOINT3427
Introduction: Recent research recognises Polycystic Ovary Syndrome (PCOS) as a multisystem condition that impacts several systems, including reproductive, dermatologic, metabolic, cardiovascular, and psychological health. Given the complexity of PCOS, a structured Model of Care (MOC) is crucial to reduce care variability. An evidence-based MOC should integrate clear referral pathways to tertiary care and align with international guidelines. The 2018 and 2023 international PCOS guidelines emphasise structured care models, yet a recent review indicated a lack of comprehensive data on implementing such models. This study aims to evaluate the characteristics of existing MOCs for PCOS care across multiple countries, assess their alignment with international guidelines, and analyse the outcomes of treatments.
>Materials and Methods: This multi-country study, conducted from May 2023 to March 2024, involved seven clinics from the United Kingdom, Turkey, Greece, India and Georgia. Clinics were invited to share their MOCs and first consultation management protocols for PCOS. Data were collected from patients seen between January 1, 2020, and December 31, 2023. The data included demographic information, clinical assessments (e.g., hirsutism, acne, metabolic screening), and biochemical tests (e.g., glucose, cholesterol, hormonal profiles). Adherence to the 2023 PCOS guidelines, including lifestyle advice and long-term risk education, was also evaluated. An online questionnaire was used to collect detailed MOC information. Data were analysed using the SPSS software version 29.0.1.1. Continuous data were assessed for normality using the Shapiro-Wilk test combined with graphical methods. Non-normally distributed data were presented as medians with interquartile ranges (IQR), while categorical data were expressed as absolute frequencies and percentages. All tests were performed at a 0.05 significance level.
Results: The study included 1,321 patients with a median age of 27 years (IQR 24-32). The most common clinical features at presentation were hirsutism (71.6%) and acne (28.7%). Screening for dermatology (86.9%), cardiometabolic health (80.9%), and reproductive health (75%) was commonly performed, but emotional well-being (37.1%) and long-term risk education (34.2%) were less frequently addressed. Biochemical testing varied widely, with hormonal (e.g., testosterone, FSH, LH) and metabolic parameters (e.g., glucose, HbA1c, lipid profile) being assessed in most cases. Significant differences were observed across countries in the types of parameters assessed and the proportion of patients diagnosed according to guidelines (overall P < 0.001).
Conclusion: This study highlights substantial variation in implementing PCOS care models across different countries, particularly in emotional well-being and long-term risk education. To improve patient outcomes globally, care practices must be standardised to align with international guidelines.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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