ECEESPE2025 Poster Presentations Reproductive and Developmental Endocrinology (93 abstracts)
Exploring the relationship between sex hormones and abdominal muscle composition in postmenopausal women: insights from the multi-ethnic study of atherosclerosis
amar osmancevic 1 , Matthew Allison 2 , Iva Miljkovic 3 , Chantal A Vella 4 , Pamela Ouyang 5 , Penelope Trimpou 6 & Bledar Daka 7
1Institution of Medicine, Sahlgrenska Academy, School of Public Health and Community Medicine, Gothenburg, Sweden; 2Division of Preventive Medicine, School of Medicine, UC San Diego, San Diego, CA, United States of America., San Diego, United States; 3Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States of America., Pittsburgh, United States; 4Department of Movement Sciences, University of Idaho, Moscow, ID, United States of America., Moscow, United States; 5Institute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America., Baltimore, United States; 6Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden, Gothenburg, Sweden; 7Institution of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
JOINT2
The relationship between sex hormone levels and muscle composition in postmenopausal women remains underexplored. To address this gap, we conducted a cross-sectional observational study utilizing data from the Multi-Ethnic Study of Atherosclerosis. Our analysis included 682 postmenopausal women aged 45-84 years with complete data, with a mean age of 63.3 years. Using abdominal computed tomography imaging, we assessed abdominal muscle area (cm2) and muscle radiodensity (Hounsfield units) in relation to serum levels of testosterone (total and free), estradiol, and sex hormone binding globulin, measured with radioimmunoassay’s, in pmol/l or nmol/l. Multivariable linear regression models, adjusting for potential confounders, were employed to investigate these associations. In our fully adjusted models, higher levels of estradiol and free testosterone were found to be positively associated with total abdominal muscle area (β = 1.41, 95% CI 0.4, 2.4, P = 0.007 and β = 18.5, 95% CI 4.0, 33.1, P = 0.004, respectively), but not with muscle radiodensity (p > 0.05). Conversely, elevated levels of SHBG were associated with lower total abdominal muscle area and radiodensity (β = -2.1, 95% CI -3.2, -0.9, P = 0.001 and β = -0.32, 95% CI -0.6, -0.0, P = 0.07, respectively). Our study highlights significant associations between sex hormone levels and skeletal muscle area in postmenopausal women. Furthermore, the novel findings regarding SHBG, and muscle composition suggest a potential previously unrecognized role of SHBG in skeletal muscle adipose tissue accumulation. However, further validation in other cohorts is necessary to elucidate the potential role of SHBG in body composition.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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