The increased coexistence of autoimmune thyroid disease (AITD) in children and adolescents with differentiated thyroid carcinoma (DTC) in years 2015-2024 compared to 1996-2000; one center experience

Marek Niedziela; Jerzy Harasymczuk; Pawel Kurzawa

doi:10.1530/endoabs.110.P1114

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Endocrine Abstracts (2025) 110 P1114 | DOI: 10.1530/endoabs.110.P1114

ECEESPE2025 Poster Presentations Thyroid (141 abstracts)

The increased coexistence of autoimmune thyroid disease (AITD) in children and adolescents with differentiated thyroid carcinoma (DTC) in years 2015–2024 compared to 1996-2000; one center experience

Marek Niedziela ¹ , Jerzy Harasymczuk ² & Pawel Kurzawa ³

Author affiliations

¹Poznań University of Medical Sciences, Karol Jonscher’s Clinical Hospital, Department of Paediatric Endocrinology and Rheumatology, Poznan, Poland; ²Poznań University of Medical Sciences, Karol Jonscher’s Clinical Hospital, Department of Paediatric Surgery, Poznan, Poland; ³Poznań University of Medical Sciences, Karol Jonscher’s Clinical Hospital, Department of Clinical Pathology and Immunology; Department of Oncological Pathology, Poznan, Poland

JOINT3789

Introduction: 37 thyroid carcinomas were diagnosed in our region in years 1996–2000, 30 in girls (81.1%) and 7 in boys (19.9%). The predominance of papillary thyroid carcinoma (PTC - 26/37 - 70.3%) compared to follicular thyroid carcinoma (FTC - 10/37 - 27.0%) and medullary thyroid carcinoma (MTC -1 - 2.7%) was observed. AITD (autoimmune thyroiditis – AIT and Graves’ disease - GD) coexisted in 1 PTC/GD among all DTCs (1/36 - 2.8% of all DTCs and 3.8% in PTC group) (Med Pediatr Oncol 2004;42:84–92).

Aim: The aim of retrospective study was to analyze the coexistence of AITD (AIT and GD) and DTC in years 2015-2024 (10-year-period) in relation to years 1996–2000 (5-year-period).

Material and Methods: Patients aged <18 years with the postoperative histopathological diagnosis of DTC were analyzed. All patients had prior ultrasound examination and US-guided fine needle biopsy of a suspicious nodule/area and thyroid aspirates were classified based on Bethesda system. AITD was confirmed/treated prior or at diagnosis of DTC by the presence of a classic clinical manifestation, hormonal profile and ultrasonographic imaging of both autoimmune thyroid disorders, AIT and GD, confirmed by specific antithyroid antibodies in serum (TPOAb/TgAb/TRAb).

Results: 75 thyroid carcinomas were confirmed in 2015–2024 (71 PTC - 94.7%, 1 FTC - 1.3% and 3 MTC - 4.0%), 57 in girls (76%) and 18 in boys (24%). MTCs were not enrolled to this analysis however all three cases had negative antithyroid antibodies. AITD was diagnosed in 37/72 (51.4%) of patients with DTC, i.e. 18-fold more frequently than in 1996–2000. A single patient with FTC had no features of thyroid autoimmunity. 5 more patients had isolated and mildly elevated TgAb (up to 3-fold to an upper limit of normal range).

Conclusions: High coexistence of PTC and AIT in years 2001–2015 suggests that the careful follow-up of patients with AIT, particularly with ultrasound examination, is mandatory to detect the cancer at early stage in this group of patients.