Endocrine Abstracts

JOINT1555

Objective: To explore the alterations in bone metabolism and bone mass in children with hyperthyroidism, both before and during puberty.

Methods: Children newly diagnosed with hyperthyroidism from January to December 2024 were recruited and categorized into two groups: pre-pubertal and pubertal. A control group of healthy children from the same period was also included. Bone metabolism markers, including bone glaprotein (BGP), type I procollagen amino-terminal propeptide (PINP), type I collagen carboxy-terminal (β-CTX), alkaline phosphatase (ALP), 25-hydroxyvitamin D (25(OH)D), and bone mineral density (BMD), were measured in both untreated hyperthyroid children and healthy controls.

Results: Pre-pubertal hyperthyroid children: Significant differences were observed in BGP (167.33±79.21), PINP (1062.96±151.36), ALP (298.28±74.19), β-CTX (1.10±0.35), and 25(OH)D (79.67±19.11) compared to the control group (P < 0.05). However, no significant difference was found in BMD (P > 0.05). Pubertal hyperthyroid children: Significant differences were observed in BGP (151.81±81.23), ALP (252.71±87.90), β-CTX (1.14±0.56), and 25(OH)D (66.12±19.27) compared to the control group(P < 0.05). No significant difference was found in PINP (P > 0.05). However, a significant difference was observed in BMD (-1.19±1.47) compared to the control group (P < 0.05).

Conclusion: Pre-pubertal children with hyperthyroidism exhibit increased bone metabolism. Pubertal children with hyperthyroidism experience bone loss.

Key Words: Hyperthyroidism, bone metabolism, bone mass, pre-pubertal children, puberty.