Iron deficiency and thyroid dysfunction: impact of iron supplementation on tsh levels in women of reproductive age in ajara georgia

Liana Jashi; Tamar Peshkova; tamar shervashidze; Mukhamed Artmeladze; Koba Kamashidze; Nino Gorgiladze; Ana Kotorashvili

doi:10.1530/endoabs.110.P1157

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Endocrine Abstracts (2025) 110 P1157 | DOI: 10.1530/endoabs.110.P1157

ECEESPE2025 Poster Presentations Thyroid (141 abstracts)

Iron deficiency and thyroid dysfunction: impact of iron supplementation on tsh levels in women of reproductive age in ajara georgia

Liana Jashi ¹ , Tamar Peshkova ² , tamar shervashidze ³ , Mukhamed Artmeladze ¹ , Koba Kamashidze ⁴ , Nino Gorgiladze ¹ & Ana Kotorashvili ¹

Author affiliations

¹AVICENNA – Batumi Medical University, Batumi, Georgia; ²Batumi Shota rustaveli State University, Batumi, Georgia; ³David Agmashenebeli University of Georgia, Tbilisi, Georgia; ⁴Univesity of Georgia, T’bilisi, Georgia

JOINT2630

Background: Iron deficiency is frequently linked to thyroid dysfunction, particularly subclinical hypothyroidism. This study evaluates the effect of iron supplementation on thyroid-stimulating hormone (TSH) levels over six weeks in women with varying iron levels.

Methods: A retrospective analysis was conducted on 17 women aged 35 to 44 years. Baseline measurements included serum ferritin, TSH, free thyroxine (FT4), and anti-thyroid peroxidase antibodies (AT-TPO). TSH levels were reassessed after six weeks of iron supplementation.

Results: At baseline, lower ferritin levels (<15 ng/mL) correlated with elevated TSH, suggesting subclinical hypothyroidism. After six weeks of iron therapy, TSH levels declined in most patients. Those with ferritin levels between 8–11 ng/mL experienced a significant TSH reduction (e.g., from 7.1 to 3.2 μIU/mL and 8.1 to 3.1 μIU/mL). Patients with ferritin >20 ng/mL showed minimal TSH fluctuations. However, participants with high AT-TPO exhibited persistent or increased TSH despite iron therapy (e.g., AT-TPO 890 IU/mL, TSH increased from 4.7 to 10.2 μIU/mL).

Conclusion: Iron supplementation effectively reduces TSH levels in iron-deficient individuals, underscoring its role in thyroid hormone metabolism. However, in autoimmune thyroiditis (elevated AT-TPO), TSH levels remained high or worsened, indicating a complex interaction. Regular iron status monitoring is crucial in managing thyroid dysfunction, particularly in individuals at risk of hypothyroidism. Further research is needed to explore the underlying mechanisms.