ECEESPE2025 Rapid Communications Rapid Communications 2: Diabetes and Insulin Part 1 (6 abstracts)
Migration background 2000-2023 in type 1 and 2 diabetes, analysis based on the DPV registry: children with Turkish background at increased risk to develop type 2 diabetes – independent of their BMI
Becker Marianne 1 , Susanna Wiegand 2 , Daniel Weghuber 3 , Susann Weihrauch-Blüher 4 , Thomas Reinehr 5 , Rudolf Oeverink 6 , Thomas Kapellen 7 , Christian Denzer 8 , Martin Tauschmann 9 , Stefanie Schmid 10,11 & Reinhard Holl 10,11
1Centre hospitalier de Luxembourg, Luxembourg, Luxembourg; 2Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; 3Paracelsus Medical University, Salzburg, Austria; 4Universitätskinderklinik Halle/Saale, Halle, Germany; 5Vestische Kinder- und Jugendklinik Universität Witten/Herdecke, Datteln, Germany; 6MVZ Medicover, Oldenburg, Germany; 7Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany; 8UNIVERSITÄTSKLINIKUM ULM, Ulm, Germany; 9Medical University of Vienna-Dept. of Pediatrics, Wien, Austria; 10Institute of Epidemiology and Medical Biometry, CAQM, Ulm University, Ulm, Germany; 11German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany
JOINT1767
Introduction: Certain ethnicities – as native Americans and non-Hispanic Blacks in American cohorts- are known to have a higher risk to develop type 2 diabetes (T2D). As European cohorts differ substantially in migration background from American cohorts, we examined the migration background (mb) in a large pediatric German-Austrian-Suisse-Luxemburgish cohort.
Methods: The analysis was based on the DPV registry. Patients documented 2000-2023 with either type 1 (T1D) or T2D, younger than 18 years and diagnosed at the age of 6- 18 years were included. Mb is defined as either the child or one of the parents being born in another country. Mb was divided in the following groups: no mb, Turkish, African, East European, South European and Syrian/Iran/Irak/Jemen/Afghanistan (SIIJA). Statistical analysis was performed using the Wilcoxon rank sum test for continuous and Chi-square test for qualitative variables with adjustment for multiple testing (Bonferroni step-down). For longitudinal observations, adjusted regression models were used.
Results: 70866 children with T1D and 2796 with T2D were included. Between 2000 and 2023, the rate of migration background increased in the total cohort from 3.2 to 29%. In the T2D group more children than in the T1D group had a migration background (33.7 vs 20.2%, P=0.00). Distribution of countries of origin differed between the two groups: More patients with T2D came from Turkey (8.9 vs 2.7%), Africa (2.9 vs 1.7%), SIJJA (2.7 vs 1.6%) and Southern Europa (3.7 vs 2.6%) compared to T1D (all P<0.0005). At diagnosis, Turkish T2D patients were not more obese than patients with no mb, HbA1c and age were similar. In regression models adjusted for age, gender, diabetes duration and HbA1c, there was no significant difference in BMI between Turkish and no mb T2D patients (P=0.48).
Conclusion: Mb increased corresponding to the overall increase of mb in the general population (29% in Germany in 2023). We observe distinct differences in migration background between pediatric T1D and T2D cohorts. Pediatric T2D had more often a Turkish background. This difference could not be explained by differences in BMI. We hence postulate, that Turkish patients seem to have a higher genetic risk to develop T2D.
Volume 110
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Endocrine Abstracts
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