BSPED2025 Poster Presentations Bone (8 abstracts)
Bone mineral density and vertebral fractures in teenage and young adult patients with acute lymphoblastic leukaemia. a report from the british osteonecrosis study
Aidan Kirk 1 , Beki James 2 , Richard Feltbower 3 , Talat Mushtaq 2 , Elizabeth Whitehead 2 , Jeannette Kraft 2 , Jayashree Motwani 4 , Holly Parkin 4 , Jane Guest 4 , Juliet Gray 5 , Jenni Palmer 6 , Jennifer Pelling 6 , Jenny Appleby 6 , Naomi Ledwich 6 , Tatendashe Dondo 3 & Nadia Amin 2
1Mid Yorkshire Teaching Hospital NHS Trust, Wakefield, United Kingdom; 2Leeds Children’s Hospital, Leeds, United Kingdom; 3Leeds Institute for Data Analytics, Leeds, United Kingdom; 4Birmingham Children’s Hospital, Birmingham, United Kingdom; 5Centre for Cancer Immunology, Southampton, United Kingdom; 6Southampton Children’s Hospital, Southampton, United Kingdom
Introduction: The British Osteonecrosis Study (BONES) is the first multicentre prospective study assessing bone health and vertebral fractures in patients aged 10-24 in the UK undergoing treatment for acute lymphoblastic leukaemia (ALL) or lymphoblastic lymphoma (LBL).
Methods: 61 patients were recruited from 3 tertiary centres in the UK. Dual-energy x-ray absorptiometry (DXA) scans with vertebral fracture analysis were performed within 4 weeks of diagnosis and annually for 3 years. Subjective pain assessments were performed at the same timepoints.
Results: Bone mineral density (assessing total body less head (TBLH) significantly reduced after 2-years, compared to baseline (estimate = -0.964, 95% CI [-1.357, -0.572]), with greatest decrease occurring within the first year. Vertebral fracture prevalence was 4.9%, with 2 further patients experiencing incident vertebral fractures. All vertebral fractures occurred in male patients, 75% of whom were British Asian. Back pain was not a predictor of low BMD or vertebral fractures.
Discussion: We report a lower vertebral fracture prevalence in patients aged 10-24 with ALL than has been previously reported in a cohort of younger patients. Male British Asian patients appeared to be at higher risk of vertebral fractures in this study. BMD and pain were not predictors of vertebral fractures.
Volume 111
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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