Endocrine Abstracts

Background: In 2020 the NHS Blood and Transplant authority and the Liver Advisory Group agreed to a pilot scheme to determine the benefits of liver transplantation for unresectable neuroendocrine tumour liver metastases. A national delivery framework was set up, through University Hospitals Birmingham (UHB), in mid-2021. It has been selecting patients for the pilot programme through a national multidisciplinary team meeting (nMDT) held once monthly. The nMDT provides oversight and expert guidance for selecting eligible patients who will benefit from entering the liver transplant pathway.

Aims: To demonstrate the work of the national pilot programme, in delivering the programme. Promoting awareness and education for other health care professionals, to improve access to liver transplantation for eligible patients across the United Kingdom (UK) and Ireland.

Methods: Data has been collated from the designated national liver transplant database.

Results: 41 nMDT meetings

56 referrals to the nMDT from 18 centres

9 patients suitable for Liver Transplantation

25 patients potentially suitable for Liver Transplantation

22 patients not suitable for Liver Transplantation

8 patients received a Liver Transplant within the pilot programme

• 2 Male

• 6 Female

• Age range 44-64, mean age 53.4

• Grade 1-2 Well- differentiated NET

• 7 GI Primary

• 1 Pancreatic Primary

All 8 patients remain under active follow-up

Conclusion and Future Plans: A pilot study in the United Kingdom and Ireland is providing further evidence to determine the role of liver transplantation in NETs, by making strategic use of the combined expertise in NETs and liver transplantation that exists in the UK and Ireland. Required infrastructure has been developed to deliver a successful programme. This pilot places UK and Ireland at the forefront for developing international clinical trials in liver transplantation for the indication of neuroendocrine cancer, as well as other trials and research in this field. Ongoing robust data capture is being achieved. This will facilitate a comprehensive analysis, of the utility of liver transplantation in NETs.