IES2025 Case Reports E-Posters (18 abstracts)
Case report: rapid progression of diabetic retinopathy during pregnancy in a woman with ABCC8-mody
Patrick McCluskey 1 , Mairéad T. Crowley 1 , Cosmina Barac 1 , Maria Kennelly 2 & Maria M. Byrne 1
1Mater Misericordiae University Hospital, Dublin, Ireland; 2Rotunda Maternity Hospital, Dublin, Ireland
We describe an uncommon presentation of rapid progression of clinically significant diabetic retinopathy during pregnancy in a woman with a rare form of diabetes, ABCC8-MODY. The subject’s clinical history, diabetic management, laboratory results, continuous glucose monitoring data, and retinal imaging obtained during pregnancy are examined. Target glycemic control was achieved by the end of the first trimester using insulin therapy and remained controlled for the duration of the pregnancy. Routine retinal imaging in the second trimester noted progression to active proliferative retinopathy which required four sessions of panretinal photocoagulation to each eye. There was no associated loss of visual or nephropathy. We suggest that there is a theoretical possibility that the ABCC8 pathogenic variant results in changes to SUR1 which may contribute to the rapid progression of clinically significant diabetic retinopathy.
Volume 115
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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