IES2025 Research, Audit and Quality Improvement Projects Physical Posters (55 abstracts)
The impact of metabolic complications in pregnancy on later life maternal cardiometabolic health: findings from the ROLO longitudinal cohort study
Kristyn Dunlop 1 , Sophie Callanan 1 , Catherine McNestry 1 , Catherine Phillips 2 , Rachel K Crowley 3,4 , Kaat Philippe 2 , Alexander Douglass 2 , Ricardo Segurado 1 , Patrick Twomey 5 & Fionnuala M McAuliffe 1
1UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland; 2School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Dublin, Ireland; 3School of Medicine, University College Dublin, Dublin, Ireland; 4Department of Endocrinology, St Vincent’s University Hospital, Dublin, Ireland; 5Department of Clinical Chemistry, St Vincent’s University Hospital, Dublin, Ireland
Pregnancy is a physiological “stress test” for women’s health, where pregnancy-induced metabolic complications associate with later-life risk of cardiometabolic disease. Pregnancy and the puerperium may represent an opportunity to improve long-term cardiometabolic outcomes. We hypothesise metabolic complications in pregnancy (pregnancy-induced hypertension, impaired glucose tolerance, gestational diabetes) will be associated with lasting effects on maternal cardiometabolic health. Health and lifestyle data were obtained from 422 women during pregnancy and 10 years postpartum. Anthropometry, dual-energy X-ray absorptiometry scans and non-fasting blood samples were recorded 10 years postpartum. Crude and adjusted linear regressions explored associations between pregnancy metabolic complication and cardiometabolic risk profile. The mean (SD) age at follow up was 42.7 (3.9) years. The rate of T2DM was 0.02% (n = 7), and 100% of these women had a pregnancy metabolic complication. Women who experienced pregnancy metabolic complications (n = 117, 27.9%) had significantly higher median BMI at study entry, and higher rate of non-white Irish ethnicity. Pregnancy metabolic complications were associated with greater postpartum weight retention (B=1.72, 95% CI 0.08,3.36, P = 0.040), higher BMI (B=0.70, 95% CI 0.09,1.31, P = 0.025), greater visceral adipose tissue mass (B=0.12, 95% CI 0.01,0.23, P = 0.033), greater total cholesterol (B=0.36, 95% CI 0.15,0.58, P = 0.001), greater LDL-cholesterol (B=0.29, 95% CI 0.09,0.50, P = 0.005), greater triglycerides (B=0.06, 95% CI 0.03,0.32, P = 0.012), greater glucose (B=0.22, 95% CI 0.03,0.40, P = 0.022) levels and a higher cardiovascular QRISK 3 score (B=0.28, 95% CI 0.08,0.49, P = 0.006) at 10 years postpartum. In conclusion, metabolic complications in pregnancy were associated with persistent alterations in maternal cardiometabolic profile at 10 years postpartum.
Volume 115
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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