Endocrine Abstracts

Type 2 diabetes mellitus and obesity are well-known risk factors for non-alcoholic fatty liver disease (NAFLD). The purpose of our study was to compare the prevalence of NAFLD in obese patients awaiting bariatric surgery between those with and without diabetes. 245 people who underwent Bariatric surgery from 2013 to 2022 at Colombo South Teaching Hospital, Sri-Lanka, were retrospectively analyzed for the presence or absence of diabetes and hepatic parameters indicating FL, including liver transaminases and ultrasonography evidence. 109 (44.4%) had diabetes, of them 31% were males, 69% were females, mean age was 40.6±10.2, mean weight was 115.8 kg ±24.4(range 75-204), mean BMI was 45.4kg/m2 ±7.4 (range 31.2-68.1), mean fasting plasma glucose (FPG) was 140mg/dl, and mean HbA1c was 8.5%. 84 were on oral hypoglycemics and 24 were on insulin. 136 (55.6%) of pre-bariatric surgery population had no diabetes. Mean age was 34.3years±9.9 (range of 15-57). Majority (73%) were females. Mean weight and mean BMI were 121kg+/-45.3 and 45.6kg/m-2, respectively. Mean FPG was 95mg/dl and mean HbA1c was 5.5%. Diabetes group had mean AST of 35u/l±20.7 among females and 39.1u/l±18.4 among males, mean ALT was 45±27.3u/l in females and 48.8±21.4 u/l in males. Non diabetes group had AST of 22±13.1 u/l among females and 29.3±13.2u/l among males with a mean ALT of 32±22.8 u/l for females and 37.6±21.2u/l for males. 88% of diabetes group had FL on ultrasonography, (grade 1 in 34%, grade 2 in 60% and grade 3 in 6.2%). Non-diabetes group had FL among 57% (grade 1 in 54%, grade 2 in 42% and grade 3 in 4%). Results indicate, obese pre-operative bariatric surgery population with T2DM has high prevalence of NAFLD compared to non-diabetes population as evident by both raised liver transaminases and ultrasonography.