Endocrine Abstracts

Since earlier publications revealed a prominent and versatile impact of the neuromedin peptide family on several neuroendocrine processes, in the present experiments we focused on the effects of a recently discovered member of neuromedines, neuromedine S on such phenomena as open-field behaviour and hypothalamic-pituitary-adrenal (HPA) activation. The peptide was administered intracerebroventricularly to freely moving rats and 30 minutes later the aforementioned neuronedocrine...

Hypocalcemic cardiomyopathy due to hypoparathyroidism is a very rare condition which responds favorably to vitaminocalcic treatment.We report the case of a 50 years old man who presented to our unit for general fatigue, apathy and cough lasting several years with a worsening during the last months, there was biological evidence of hypoparathyroidism with profound hypocalcemia (21 mg/l) hyperphosphoremia (53 mg/l) and undetectable PTH levels the CT scan s...

Numerous clinical manifestations have been described in association with Cushing’s disease (CD). There was no eligible data on pulmonary function tests in CD patients. We aimed to assess pulmonary function test included spirometry in a series of patients with active Cushing’s disease (2 men, 9 women). Mean age, height, weight, body mass index were 36.7±12.6 (range 22–63 years), 156.9±8.4 cm, 74.1±10.7 kg, 29.6±3.8 kg/m2, respective...

Hypoglycaemia, a life threatening complication, occurs as part of a wide variety of disease processes. Though a common side effect of diabetes medications, it can be secondary to other factors including, endocrine and, metabolic disorders, severe sepsis, rare malignancies and non-diabetic medications. We present a case series of 3 non-diabetic patients who presented to Princess of Wales, Bridgend with Hypoglycaemic Episodes (HE):1. 23 year old student nu...

Introduction: Prostate carcinoma is a recognised yet rare cause of Cushing’s syndrome. This report describes two cases in which Cushing’s syndrome was associated with advanced prostate cancer.Case 1: A 70-year man presented with a very short history of swelling of his face and legs. He was known to have prostate adenocarcinoma with bony metastases. He was hypokalaemic and resistant to standard potassium replacement. He had a Cushingoid appearan...

Pituitary disorders are relatively uncommon conditions which leave patients feeling isolated and distressed. Acromegaly and Cushing’s are associated with obvious and visible differences to appearance, while other pituitary conditions are associated with profound, yet hidden, physical changes which impact significantly on psychological well being.AimTo explore the subjective experiences of patients living with and managing a pi...

Background: The general population trend shows an increase in the elderly. The most affected systems in the aging process are the endocrine and cardiovascular systems. The cardiovascular conditions are very important among the diseases of the elderly, the mortality due to cardiovascular diseases holding the first place in geriatrics.The aim of the study is to determine the peculiar aspect of dehydroepiandrosterone sulfate secretion dynamics in the elderl...

Introduction: Cushing’s syndrome denotes pathologic hypercortisolism as a result of excessive adrenocorticotropic hormone (ACTH) production or autonomous adrenal production of cortisol according to the ACTH levels. However, 30% of the patients with CS have ACTH levels in the ‘grey zone’ (5–20 pg/ml), thereby posing a challenge in establishing the aetiological diagnosis.Case presentation: A 20-year-old woman presented to our depart...

PURPOSE: To report a case of Cushing’s syndome caused by ectopic ACTH secretion related to a thymic carcinoid presented with trombositopenia.CASE: years old male presented with fatigue, skin rash. At presentation, physical findings showed Cushingoid appearance, with moon face, hyperpigmentation, easy bruising and buffalo hump. His laboratory findings showed platelet: 90.000 (150.000–450.000), ACTH: 609 pg/ml (0–46 pg/ml), baseline cortisol...

A 68-year-old woman presented with hypertension, oedema, weight gain and moon face. She had signs of proximal muscle weakness, thinning of scalp hair and bruising on her legs. Initial tests showed 24 hour urine free cortisol elevated at 946 nmol (0–300 nmol).Serum cortisol showed no circadian fluctuation (0900: 1094 nmol/l, 2400 hrs: 886 nmol/l) and no suppression by dexamethasone (2 mg/24 h for 48 h: 1067 nmol/l). ACTH levels were slightly raised (...