Searchable abstracts of presentations at key conferences in endocrinology

ea0070s4.3 | Unveiling signatures in pituitary neuroendocrine tumours | ECE2020

Unravelling the PitNET methyloma

Pico Antonio

Context: Pituitary tumorigenesis does not fit into the most common model of cancer development driven by gene mutations. Instead, epigenetic mechanisms have been widely involved. Among them, aberrant DNA methylation at CpG sites is one of epigenetic hallmarks of tumour cells. There are several methods to study the epigenetic regulation of genome activity, from DNA methylation arrays to more specific DNA methylation analysis such as pyrosequencing, Methylation-Specific PCR (MS-...

ea0032s32.2 | Is diabetes a lipid disease? | ECE2013

Fatty liver disease

Moschetta Antonio

Nonalcoholic fatty liver disease (NAFLD) is becoming a master component of the epidemic of obesity and metabolic syndrome worldwide due to excessive caloric intake. The spectrum of NAFLD ranges from simple fatty liver with benign prognosis to a potentially progressive form, nonalcoholic steatohepatitis (NASH), which may lead to liver fibrosis and cirrhosis resulting in increased morbidity and mortality. Development of hepatic steatosis and its progression to steatohepatitis ma...

ea0020s15.2 | Progress in understanding and management of diabetes | ECE2009

The metabolic memory

Ceriello Antonio

Large randomized studies have established that early intensive glycemic control reduces the risk of diabetic complications, both micro and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as ‘Metabolic Memory.’ It was first hypothesized by Brownlee (Nature 2000), and since shown by many researchers that overproduction of free radicals, ...

ea0015s22 | Thyroid hormones in development: physiology and clinical implications | SFEBES2008

New roles of deiodinases in development

Bianco Antonio

Thyroid hormone 3,5,3′-triiodothyronine (T3) and its precursor thyroxine (T4) are iodinated compounds known to influence gene expression in virtually every vertebrate tissue. Fundamentally, thyroid hormone signaling results from the interaction of nuclear thyroid hormone receptors (TRs) with specific target gene promoters, a process that can either enhance or repress transcription. This process is modulated via binding of thyroid hormone, the ligand...

ea0094pl1.1 | Clinical Endocrinology Trust Visiting Professor Lecture | SFEBES2023

Are we restoring thyroid hormone signaling in patients with hypothyroidism?

Bianco Antonio

The binding of T3 to its nuclear receptors (TR) triggers T3 signaling, modulating the expression of thousands of genes. These events are reversible and fluctuate according to the T3 levels. In developing tissues, T3 signaling also modifies chromatin folding, permanently affecting gene expression throughout life. Hypothyroidism occurs when, at any time, there is insufficient T3 signaling, frequently due to low plasma thyroid hormone levels. The treatment is with levothyroxine (...

ea0050pl9 | Society for Endocrinology Medal Lecture | SFEBES2017

Adipose tissue expandability, lipotoxicity and the metabolic syndrome

Vidal-Puig Antonio

The link between obesity and type 2 diabetes is clear on an epidemiological level, however the mechanism linking these two common disorders is not well defined. One hypothesis linking obesity to type 2 diabetes is the adipose tissue expandability hypothesis. The adipose tissue expandability hypothesis states that a failure in the capacity for adipose tissue expansion, rather than obesity per se is the key factor linking positive energy balance and type 2 diabetes. All individu...

ea0050pl9 | Society for Endocrinology Medal Lecture | SFEBES2017

Adipose tissue expandability, lipotoxicity and the metabolic syndrome

Vidal-Puig Antonio

The link between obesity and type 2 diabetes is clear on an epidemiological level, however the mechanism linking these two common disorders is not well defined. One hypothesis linking obesity to type 2 diabetes is the adipose tissue expandability hypothesis. The adipose tissue expandability hypothesis states that a failure in the capacity for adipose tissue expansion, rather than obesity per se is the key factor linking positive energy balance and type 2 diabetes. All individu...

ea0037s27.1 | Thyroid cancer: new development in diagnosis and treatment (<emphasis role="italic">Endorsed by the European Journal of Endocrinology</emphasis>) | ECE2015

Central neck dissection: an important step forward in the management of thyroid papillary cancer

Sitges-Serra Antonio

Endorsed by the European Journal of Endocrinology )-->Central neck dissection for papillary thyroid cancer (PTC) was initially proposed by Scandinavian authors in the late 70’s on the following grounds: i) the common presence of obvious metastatic nodal disease in compartment VI; ii) compartment VI is the first step in lymph node dissemination of PTC; and iii) prevents cancer recurrence in the ce...

ea0031pl5 | British Thyroid Association Pitt-Rivers Lecture | SFEBES2013

BTA_Pitt Rivers Lecture

Bianco Antonio C

A C Bianco is a professor of medicine and Chief of the Division of Endocrinology, Diabetes and Metabolism at the University of Miami Miller School of Medicine. Dr A C Bianco obtained his MD, PhD and clinical training in internal medicine and endocrinology in Sao Paulo, Brazil. His work has established the importance of the local control of thyroid hormone activation/inactivation via deiodination, as well as fundamental cellular and molecular properties of the deiodinases (D1, ...