Searchable abstracts of presentations at key conferences in endocrinology

ea0028p124 | Clinical practice/governance and case reports | SFEBES2012

Non-compliance in a childhood cancer survivor

Gorick Sondra , Temple Rosemary

We present the case of a 24 year old childhood cancer survivor with non-compliance of medication. Patient SB d.o.b. 30/07/1987, presented with a squint and loss of vision in the right eye at the age of four years. He was diagnosed with a craniopharyngioma and had a frontal craniotomy. Two years later, an MRI showed recurrence so he had further frontal surgery followed by irradiation (50 Gy in 28 fractions). Post operatively he was diagnosed with panhypopituitarism and remained...

ea0023p14 | (1) | BSPED2009

Growth restriction with insufficient growth hormone production in a child with variant Miller-Dieker syndrome

Marsh Rosemary , Raine Joseph

Introduction: We describe a girl presenting with abnormal facial features, growth restriction with insufficient growth hormone production and learning difficulties. She has an unbalanced translocation between 17p13.3 and 10q26.13 causing a microdeletion at 17p13.3 and trisomy of 10q26.Case report: At presentation at 7½ years of age, her height was 4 cm below the 0.4th centile with a growth velocity of 1.6 cm/year; weight was on 0.4th centile. Invest...

ea0015p59 | Clinical practice/governance and case reports | SFEBES2008

Difficulties with insulin stress tests in an adult survivor of childhood malignancy

Gorick Sondra , Temple Rosemary

Introduction: Research suggests long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome including insulin resistance (IR) despite many survivors of childhood malignancy if anything being underweight. It has been suggested growth hormone deficiency may be a factor in IR.Case report: We present a 20-year-old boy with partial hypopituitarism following allogenic bone marrow transplant in 1993 for treatment of acut...

ea0034p427 | Thyroid | SFEBES2014

Renal function in goitrous patients attending endocrinology clinic in a South Western Nigerian hospital

Ojo Olubukola , Ojo Olalekan , Ikem Rosemary

Introduction: Thyroid disorders are the second most common endocrine disorders after diabetes mellitus. These disorders are associated with cardiovascular complications which increase morbidity and mortality in affected patients. The kidney normally plays an important role in the metabolism, degradation, and excretion of several thyroid hormones. The study sets out determine renal function in patients with goiter.Methodology: The study design was cross s...

ea0031p119 | Clinical practice/governance and case reports | SFEBES2013

A question of GH deficiency or not

Gorick Sondra , Powell Katherine , Temple Rosemary

We present a 45-year-old lady who initially presented with neurological symptoms and MRI was noted to show asymmetry of the pituitary gland. There were no endocrine symptoms. In 2011 she developed some visual symptoms (not typical of pituitary disease) and was referred to the ophthalmic department. MRI scan showed an 11 mm right-sided pituitary lesion and she was referred to the endocrine department. She gave a 2-year history of feeling increasingly unwell with back pain, sens...

ea0025p209 | Nursing practise | SFEBES2011

Audit of low dose dexamethasone suppression test to exclude androgen secreting tumours in hyperandrogenic women

Powell Katherine , Temple Rosemary , Swords Francesca

The low dose dexamethasone suppression test (LDDT) is used routinely to exclude Cushings. This test can also be used to exclude androgen secreting tumours in females with elevated testosterone levels through normalisation of, or >40% suppression of serum levels.We have audited the use of the LDDT to assess its value in investigating women with raised androgens, to ascertain whether it reduced the need for other investigations and to identify any prob...

ea0015p232 | Pituitary | SFEBES2008

Assessment of quality of life and body image in adult patients with acromegaly and patients with other pituitary tumours

Chen Kirstie , Gorick Sondra , Temple Rosemary

Aims: There is a lack of literature about mental and emotional dysfunction in patients with acromegaly or other pituitary tumours although impaired quality of life is well recognised. We examined whether adult patients with acromegaly experience a lower quality of life (QoL) than adult patients with other pituitary tumours and whether any difference in QoL is attributable to the patient’s perceived body image.Methods: Medical records were used to id...

ea0013p196 | Diabetes, metabolism and cardiovascular | SFEBES2007

An assessment of some lung function parameters in Nigerian males with diabetes mellitus

Kolawoleo Babatope , Ikem Rosemary , Erhabor Gregory

Background: Despite scarce information on the implications of diabetes for pulmonary function, existing evidence suggests that the respiratory system might also be affected by diabetes. We therefore conducted a cross-sectional study of pulmonary function in our male diabetics using spirometric indices.Study design: This was a cross-sectional study of pulmonary function in diabetics. Seventy-six male diabetics aged 27–80 years, mean 55.4±12.6 we...

ea0094p180 | Adrenal and Cardiovascular | SFEBES2023

The golden ratio for cortisol replacement

Evans Rosemary , Gallagher Meurig , Smith David

Current cortisol dosing regimes for patients with adrenal insufficiency are unable to accurately replicate the physiological profile of healthy patients. This work is part of an interdisciplinary study with the aim of using mathematical approaches to understand the treatment strategies for patients with adrenal insufficiency. We also aim to then tailor treatments specific to an individual or situation. We present a simplified model of hydrocortisone delivery via intravenous bo...

ea0038p58 | Clinical practice/governance and case reports | SFEBES2015

Vitamin D deficiency in haemodialysis patients; treatment with colecalciferol

Huish Sharon , Fletcher Simon , Dunn Janet , Hewison Martin , Bland Rosemary

End stage renal disease (ESRD) is characterised by decreased renal synthesis of 1,25-dihydroxyvitamin D (1,25D). Therapeutic use of 1,25D analogues for the management of renal bone disease is routine. However ESRD patients are also deficient in 25D (the immediate precursor of 1,25D). Since 2014 UK guidelines recommend diagnosis and treatment of 25D deficiency/insufficiency in people with chronic kidney disease, but make no recommendations for dosage or monitoring. This, togeth...