Endocrine Abstracts

Introduction: Von Hippel–Lindau syndrome (VHL) is an autosomal dominantly inherited neoplastic disorder with marked phenotypic variability, characterized by a broad spectrum of clinical manifestations in central nervous system (CNS) and viscera. Specific gene mutation can be demonstrated; however imaging plays an important role in diagnosis. 68Ga-labelled somatostatin analog (68Ga-DOTANOC) PET-CT is routinely employed for somatostatin receptor (SSTR) imaging, mainly for n...

Introduction: Graves’ disease (GD) is a systemic autoimmune disease characterized by lymphocyte activation and synthesis of anti-TSH receptor antibodies (TRABs). Higher values of TRABs are associated with a higher risk of Graves’ ophthalmopathy and dermatopathy. Iodine-131 therapy (RAI) is one of the well-established options in GD, but it can cause a transient increase in TRABs.Objectives: To evaluate the evolution of TRABs after RAI; to identi...

Aim: Stimulated thyroglobulin (sTg), measured at radioiodine remnant-ablation (RRA) in patients with differentiated thyroid cancer(DTC), is an important predictive factor of persistent disease. However, Tg produced by normal thyroid cells may also contribute to the sTg value.We aimed to study the relationship between sTg-level in RRA and the thyroid remnant size (TRs), using post-therapy whole-body scan (131I-ptWBS), at different TSH stimulation method.<...

Introduction and purpose: 177Lu-[DOTA0,Tyr3]octreotate (177Lu-DOTA-TATE) is a radiopharmaceutical frequently used in peptide receptor radionuclide therapy (PRRT), which is a promising treatment modality in patients with metastasized neuroendocrine tumors (NETs). We purpose to evaluate the quality of life (QoL) in patients with somatostatin receptor positive inoperable or metastatic NETs throughout the three cycle’s (with three months intervals) proto...

Introduction: Medullary thyroid carcinoma (MTC) occurs in a hereditary pattern in 25% of cases. Virtually all patients with multiple endocrine neoplasia 2A (MEN2A) develop MTC. MTC aggressiveness and natural history varies according to the RET mutation. Prophylactic thyroidectomy may cure and/or prevent metastatic disease in most cases.Case report: A 27-year-old man with past history of colostomy at 5 months of age for Hirschsprung disease and t...

Introduction: Radioiodine (RAI) therapy is an inexpensive and reliable therapeutic option for Graves’ disease (GD). However, individual characteristics of the disease can influence therapeutic success. The identification of these factors may help to predict outcome and select optimal pre-treatment conditions.Aim: To assess clinical, laboratory and radioactive parameters that may lead to RAI treatment failure in patients with GD....

Introduction: Radioiodine (131I, RAI) is a safe and effective option for the treatment of Graves’ disease (GD). However, approximately 20% of RAI treated patients will have persistent disease or will relapse after the first treatment. Our aim was to identify the factors influencing the outcomes in RAI treatment for GD.Methods: We analysed 143 DG patients (116 women) treated with RAI between October 2002 and April 2014 and ≥12 months...

Introduction: In patients with well-differentiated thyroid cancer (DTC) low/undetectable thyroglobulin (Tg) at time of remnant ablation usually reflects a complete previous surgery. However, in a small percentage (6.3–16%) it can represent false negative values.Objectives: Evaluate the frequency of patients with low/undectable Tg at time of remnant ablation with locoregional or distant lesions at post-ablative 131I whole body scan (WBS) a...

Introduction: Subclinical Cushing’s syndrome (SCS) is the most frequent endocrine dysfunction found in adrenal incidentalomas. Although adrenalectomy constitutes a therapeutic option for selected cases, the presence of bilateral tumours can difficult the surgical decision.Objective: Evaluate the utility of 131I-6β-iodomethyl-19-norcholesterol scintigraphy in SCS with bilateral adrenal tumours.Methods: Retrospec...

Introduction: The TNM staging system for well differentiated thyroid cancer (WDTC) considers tumours over 4 cm diameter limited to the thyroid or tumours with minimal extra-thyroid extension to be classified as pT3. This stage can be considered quite heterogeneous, as different clinical and pathologic characteristics seem to have distinct prognosis value.Aims: To determine prognostic factors amongst clinical, laboratorial, histologic and radiologic chara...