Searchable abstracts of presentations at key conferences in endocrinology

ea0013s5 | The British Thyroid Association Pitt Rivers Lecture | SFEBES2007

Genes that mediate thyroid hormone functions in development

Forrest Douglas

Thyroid hormone is critically important for many developmental processes. However, less is known about how this hormone elicits its actions, a question that becomes more puzzling given that that distinct target tissues respond in different ways and often at different times. How does this systemic hormonal signal elicit its diverse responses? Targeted mutagenesis of thyroid hormone receptors (TR) encoded by the Thrb and Thra genes has indicated that some specifici...

ea0094esd1.2 | Section | SFEBES2023

Advice and guidance

Robertson Douglas

There have always been conversations between clinicians about management and potential referral of patients, predominately from primary care to specialists. This has been called variously ‘advice and guidance (A&G)’, ‘specialist advice’ or ‘advice and refer’ by NHS England (NHSE). In the last few years, A&G has become increasingly relevant with escalating clinic pressures and is now part of the NHSE/GIRFT ‘elective care recovery and t...

ea0003p216 | Reproduction | BES2002

Activation of supraoptic nucleus (SON) oxytocin neurones during mouse parturition

Douglas A , Willen S

Oxytocin drives parturition by contracting the uterus, but transgenic mice with no oxytocin appear to give birth normally. We have previously shown that oxytocin antagonist administration delays births showing that oxytocin plays a role in normal mouse parturition. Here, we tested the hypothesis that oxytocin neurones are active during parturition, using double immunocytochemistry for Fos and oxytocin to show neuronal activation and radioimmunoassay of blood samples to seek in...

ea0014p583 | (1) | ECE2007

The endocrine and behavioural actions of neuromedine S

Jászberényi Miklós , Bagosi Zsolt , Szabó Gyula , Telegdy Gyula

Since earlier publications revealed a prominent and versatile impact of the neuromedin peptide family on several neuroendocrine processes, in the present experiments we focused on the effects of a recently discovered member of neuromedines, neuromedine S on such phenomena as open-field behaviour and hypothalamic-pituitary-adrenal (HPA) activation. The peptide was administered intracerebroventricularly to freely moving rats and 30 minutes later the aforementioned neuronedocrine...

ea0011p98 | Clinical case reports | ECE2006

Hypocalcemic cardiomyopathy in a patient with primary hypoparathyroidism and Fahr’s disease

Azzoug S , Chentli F

Hypocalcemic cardiomyopathy due to hypoparathyroidism is a very rare condition which responds favorably to vitaminocalcic treatment.We report the case of a 50 years old man who presented to our unit for general fatigue, apathy and cough lasting several years with a worsening during the last months, there was biological evidence of hypoparathyroidism with profound hypocalcemia (21 mg/l) hyperphosphoremia (53 mg/l) and undetectable PTH levels the CT scan s...

ea0011p600 | Neuroendocrinology and behaviour | ECE2006

Pulmonary function in Cushing’s disease

Bayraktaroglu T , Kutluturk F , Turan E , Orhan Y , Tanyolac S

Numerous clinical manifestations have been described in association with Cushing’s disease (CD). There was no eligible data on pulmonary function tests in CD patients. We aimed to assess pulmonary function test included spirometry in a series of patients with active Cushing’s disease (2 men, 9 women). Mean age, height, weight, body mass index were 36.7±12.6 (range 22–63 years), 156.9±8.4 cm, 74.1±10.7 kg, 29.6±3.8 kg/m2, respective...

ea0077p62 | Metabolism, Obesity and Diabetes | SFEBES2021

Hypoglycaemia in non-diabetics. An Endocrinologist’s perspective

Sharaf Giselle , Bhagi Ridhi , Morgan Georgia , Cozma S. Lawrence , Roy Chowdhury Sharmistha

Hypoglycaemia, a life threatening complication, occurs as part of a wide variety of disease processes. Though a common side effect of diabetes medications, it can be secondary to other factors including, endocrine and, metabolic disorders, severe sepsis, rare malignancies and non-diabetic medications. We present a case series of 3 non-diabetic patients who presented to Princess of Wales, Bridgend with Hypoglycaemic Episodes (HE):1. 23 year old student nu...

ea0014p44 | (1) | ECE2007

Low dose cyclosporin and methotrexate administration induces remission of Type 1 diabetes mellitus

Sobel Douglas , Abbassi Val , Henzke Annette

Although, high doses of cyclosporine (cyclo)has been demonstrated to inhibit the development of type 1diabetes mellitus (T1D), its usefulness was limited by its toxicity. Since methotrexate (Mtx) and cyclo have been shown to synergistically act in other disease processes, we determined if low dose cyclo and Mtx therapy could inhibit the development of diabetes and reduce or eliminate the need for insulin therapy in a pilot study.Methods: Insulin dose and...

ea0013p49 | Clinical practice/governance and case reports | SFEBES2007

Severe cushing’s syndrome associated with metastatic prostate adenocarcinoma

Elmalti Akrem , Arefin AN , Thomas M , Jenkins R , Orme S

Introduction: Prostate carcinoma is a recognised yet rare cause of Cushing’s syndrome. This report describes two cases in which Cushing’s syndrome was associated with advanced prostate cancer.Case 1: A 70-year man presented with a very short history of swelling of his face and legs. He was known to have prostate adenocarcinoma with bony metastases. He was hypokalaemic and resistant to standard potassium replacement. He had a Cushingoid appearan...

ea0012p84 | Pituitary | SFE2006

Cinderella’s story: the psychosocial impact of pituitary conditions

Osbourne M , Jackson S , Morris M , Ashley K

Pituitary disorders are relatively uncommon conditions which leave patients feeling isolated and distressed. Acromegaly and Cushing’s are associated with obvious and visible differences to appearance, while other pituitary conditions are associated with profound, yet hidden, physical changes which impact significantly on psychological well being.AimTo explore the subjective experiences of patients living with and managing a pi...