Endocrine Abstracts

Glucocorticoids (GC), such as prednisolone, are widely prescribed for their anti-inflammatory and immunosuppressive properties. However, they have significant side-effects including insulin resistance and hepatic steatosis. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts 11-dehydrocorticosterone (11DHC) to active corticosterone (CORT) and thus amplifies local GC action. We hypothesise that enhanced local GC regeneration of exogenously administered GCs by ...

Background: Although early studies with IPSS reported a diagnostic sensitivity and specificity approaching 100%, additional experience has revealed a false negative rate of 1–10%. Previous studies have suggested that the measurement of other anterior pituitary hormones may be useful as a guide to the effectiveness of cannulation and to improve diagnostic accuracy.Method: In this retrospective cohort study, we reviewed all patients who had undergone ...

During this session on the controversies in the management of neonatal hypoglycaemia, I will discuss why the real controversy is not the definition of hypoglycaemia but rather what we should do when we find low glucose values. I will discuss my preferred hypoglycemia guideline recommendation. In addition I will discuss the relationship between hypoglycemia and brain damage and demonstrate to the audience that hypoglycemia is not the cause of brain damage but rather energy defi...

Private Practice is not for everyone, but can complement and enhance one’s professional life - even if one has a fairly limited involvement, hence not particularly large income. I can only speak from my personal experience. When I began I benefited from valuable advice from a senior colleague on how to inform GPs in one’s locality, how to set fees at appropriate levels and when and how much increases can be made. It is vital to have an efficient secretary to ensure l...

Private Practice is not for everyone, but can complement and enhance one’s professional life - even if one has a fairly limited involvement, hence not particularly large income. I can only speak from my personal experience. When I began I benefited from valuable advice from a senior colleague on how to inform GPs in one’s locality, how to set fees at appropriate levels and when and how much increases can be made. It is vital to have an efficient secretary to ensure l...

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If you are unfortunate enough to get NETs, and with surgical options not on the table, then at least I thought I had a reasonable head start to access the only other demonstrable treatment regime…PRRT?The equation:Australian patient + Victorian patient + Under direct care of Peter Mac team + PET scans with tumours demonstrating strong take-up of GaTate = Early TreatmentInstead of a relatively short lead...

100 years have passed since Harvey Cushing linked a basophilic pituitary adenoma to bilateral adrenal hyperplasia, and in doing so elegantly depicted the clinical phenotype of “Cushing’s syndrome. Today we are uncovering the molecular basis for these tumours and pioneering novel surgical and medical therapies to improve clinical outcome, but fortunately they remain rare. Conversely iatrogenic Cushing’s with concomitant adrenal suppression is seen in the 1% of th...

Multiple Endocrine Neoplasia type 1 (MEN1) is a highly penetrant autosomal dominant disorder characterized by the combined occurrence of parathyroid, anterior pituitary and pancreatic islet tumours. Affected individuals are also at risk from a wider spectrum of tumours, which includes thymic and bronchial carcinoids, and adrenal cortical tumours. MEN1 results from germline mutation of the MEN1 gene, which encodes the tumour suppressor protein Menin. The absence of a g...

Drug-induced hyperprolactinaemia is a frequently encountered clinical entity due to the large number of commonly prescribed medications that may influence prolactin secretion. Anti-psychotics, anti-depressants and anti-emetics are most frequently culpable, predominantly due to inhibitory effects on hypothalamic-pituitary dopamine signalling. The onset and severity of hyperprolactinaemia may be highly variable, and individuals may harbour typical symptoms (e.g. galactorrhoea, a...