Endocrine Abstracts

Th17 cells represent newly discovered CD4+T cells producing predominantly IL17A cytokines, which are involved in inflammations and autoimmune diseases. Elevated IL17 levels were demonstrated in thyroid autoimmunity and the activity of Graves’ ophthalmopathy. The relationship among IL17A, anti-thyroid antibodies, smoking, and clinical activity score of ophthalmopathy was investigated in hyperthyroid Graves’ disease. One hundred and thirty-eight patients, 62 with Grave...

Postmenopausal osteoporosis is characterized by lower bone mass, loss of structural integrity, and sometimes becomes life-threatening. The development of postmeno-pausal osteoporosis is multifactorial. Estrogen plays a preventing role in the bone resorption inhibiting the secretion of proinflammatory IL1 and TNFα cytokines. IL17 proinflammatory citokine is a new candidate in the pathogenesis of osteoporosis. IL17 levels are increased in estrogen deficiency.<p class="a...

Introduction: De Quervain’s Thyroiditis (DQT) is a self-restriction inflammatory disease of the thyroid gland that presents severe pain localized in the neck. But few cases of a painful variant of Hashimoto’s thyroiditis (HT) have been described as well. Thyroid ultrasound (US) may reveal in homogeneous hypoechoic pattern in both conditions.Case: A 51-year old woman was admitted to the Hospital of Lithuanian University of Health Sciences, Kauno...

Background: Graves’ orbitopathy (GO), also known as thyroid eye disease, is an autoimmune condition and is one of the main extrathyroidal manifestations of Graves’ disease. GO is relatively rare and usually accompanies the onset or develops soon after the Graves’ disease. We present a case of GO that developed 18 years later from total thyroidectomy. Case report: A 64-year-old men presented at the ophthalmology clinic with one-month histor...

Background: Evidences show that maternal vitaminB12 deficiency at periods of development influence metabolic status and degree of metabolic syndrome of the offspring into adulthood. VitaminB12 is required for the synthesis of methionine, which is the precursor of S-adenosyl-methionine, a key methyl donor for DNA methylation. So vitaminB12 deficiency might cause methylation changes, which are thought to alter gene expression of regulatory factors and could result in adverse met...

Background: The liver stores 10 μg cobalamin per gram protein and able to hold 50% (1–1.5 mg) of body’s B12. Making up the bulk of the liver, hepatocytes express receptors regulating cellular uptake of B12 in the liver. However, relationship between circulating and intracellular B12 levels as well as regulation of hepatic uptake of B12 is unexplored.Objective: To assess the regulation of cellular uptake and storage of B12 in hepatocytes in...

Introduction: Alopecia areata affects 0.1–0.2% of population. It’s pathogenesis has not yet been discovered, but genetic, autoimmune, vascular, psychogenic or neurological factors are being considered. It can occur in any age, but appears most commonly in late childhood, teenage or early adulthood. Alopecia areata commonly coexists with other diseases such as asthma, allergic rhinitis, atopic dermatitis, thyroid diseases and autoimmune diseases such as thyroiditis an...

The prevalence of GD (Graves–Basedow disease) in adolescents with T1DM (type 1 diabetes mellitus) is around 0.5%. Most often the diagnosis of GD in T1DM patients is made many years after the onset of T1DM. The present clinical case describes an adolescent with GD and T1DM and highlights how difficult the management of this disease can be. 17-year-old male was referred to our Department for reevaluation of Graves–Basedow disease. Patient suffered from T1DM for 14 year...

Background: Glucagon-like peptide-1 (GLP-1) concentrations are reduced by 20–50% in type 2 diabetes but studies in women with gestational diabetes mellitus (GDM) are inconclusive. Our aim was to study the GLP-1 profile during a glucose tolerance test (GTT) at GDM diagnosis and its relationship with insulin levels.Methods: A prospective study of selectively screened women was conducted. Plasma GLP-1, insulin and glucose were measured at 30-minute int...

Background: Glucagon-like peptide-1 (GLP-1) concentrations are reduced by 20–50% in type 2 diabetes but studies in women with gestational diabetes mellitus (GDM) are inconclusive. Our aim was to study the GLP-1 profile during a glucose tolerance test (GTT) at GDM diagnosis and its relationship with insulin levels.Methods: A prospective study of selectively screened women was conducted. Plasma GLP-1, insulin and glucose were measured at 30-minute int...