Searchable abstracts of presentations at key conferences in endocrinology

ea0077s4.3 | Understanding pathogenesis: development of novel treatments | SFEBES2021

Translational studies in thyroid hormone transport

Visser Edward

Thyroid hormone transporters at the plasma membrane govern intracellular thyroid hormone concentrations. MCT8 represents a key thyroid hormone transporter. MCT8 deficiency (also known as Allan-Herndon-Dudley syndrome) is a devastating developmental disorder caused by mutations in the MCT8 gene (located on the X-chromosome), with an estimated prevalence of 1:70.000 males. The phenotype comprises (1) a &#...

ea0041s11.1 | New Developments in subclinical thyroid disease | ECE2016

Thyroid function and aging: what can we learn from animal models?

Visser Edward

Since thyroid hormone is a key regulator of metabolism, changes in thyroid hormone signaling have widespread effects. Thyroid state changes during aging and vice versa lifespan is affected by thyroid state. However, underlying mechanisms remain elusive. DNA damage importantly contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair.In different mouse models of premature (DNA-repair deficient animals)...

ea0059apw2.2 | Metabolites as hormones | SFEBES2018

Short chain fatty acid signalling in human health and disease

Chambers Edward

Prospective studies and clinical trials have repeatedly demonstrated that high intake of dietary fibre reduces the incidence of metabolic diseases and their risk factors. An increased intake of dietary fibre raises the amount of undigested material available for fermentation by the gut microbiota and the production of short chain fatty acids (SCFA). SCFA have been shown to regulate energy homeostasis through various metabolic pathways and receptor-mediated mechanisms. The majo...

ea0051oc7.8 | Oral Communications 7 | BSPED2017

Out of hours telephone advice service improves emergency department attendances for diabetes related complications

Holloway Edward , Bailey Matthew

Introduction: We sought to the impact of an out of hours telephone advice service for children and young people with diabetes mellitus on Emergency Department attendance rates.Methods: In July 2014 we commenced a collaborative service for 240 patients with diabetes across two Paediatric diabetes centres- Croydon University Hospital (CUH) and St George’s University Hospital, London. Paediatric diabetes specialist nurses and consultants in Paediatric ...

ea0081ep537 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Biochemical parameters in laboratory diagnostics of metabolic syndrome

Moskalenko Olga , Kasparov Edward

MS, is defined by a combination of abnormalities, such as obesity, arterial hypertension, elevated blood sugar and cholesterol levels, type 2 diabetes mellitus and is not a disease, but represents a group of risk factors that often occur together, increasing the likelihood of severe disease. It is well known that the main reasons for the increase in the incidence of MS is a decrease in physical activity with a high-calorie diet. The aim of the study: Ass...

ea0082wa5 | Workshop A: Disorders of the hypothalamus and pituitary | SFEEU2022

A case of recurring prolactinoma in pregnancy

Mathew Susan , Jude Edward

Background: Prolactinomas are the most common functioning pituitary tumours, accounting for 40% of all pituitary adenomas. Prolactinomas may enlarge in pregnancy, the management of which may prove challenging. Case Presentation: A 23 year old lady was referred to the endocrine clinic with secondary amenorrhoea and bifrontal headaches in 2012. Biochemical tests on referral revealed: FT4- 5.8 pmol/l, TSH-1.1 mU/l, Prolactin-4432 mIU/l, LH- 4.8 IU/l, FSH- 4...

ea0082wd4 | Workshop D: Disorders of the adrenal gland | SFEEU2022

An Atypical Presentation of Addison”s Disease

Mathew Susan , Jude Edward

History: A 52-year-old woman was referred by her GP for colonoscopy in view of 7 months” history of unexplained weight loss of nearly 2.5 stones, constipation and recently detected normocytic anaemia. Her past medical history was unremarkable except for bronchial asthma that was managed with albuterol. However, on the day of the scheduled colonoscopy, she was noted to be hypotensive (BP- 63/38 mm Hg, heart rate 93 bpm) and was hence admitted for fluid resuscitation. Follo...

ea0090ep455 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Features of psycho-emotional status and quality of life in patients with metabolic syndrome

Moskalenko Olga , Kasparov Edward

Metabolic syndrome (MS) is characterized by obesity, hypertension, dyslipidemia, and insulin resistance. The severity of the clinical manifestations of MS affects the quality of life (QoL) of patients, while indicators of physical and mental health decrease. In patients, anxiety and depressive disorders in 80-90% of cases are latent, which can aggravate the course of the underlying disease. The purpose of our work is to study the psycho-emotional status and quality of life in ...

ea0090ep553 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Criteria for metabolic syndrome and assessment of biochemical indicators

Moskalenko Olga , Kasparov Edward

Metabolic syndrome (MS) is an actual problem of modern medicine. It is known that the prevalence of MS varies depending on the criteria used to determine it. It should be noted that the main criterion for MS is the central (abdominal) type of obesity. It is necessary to adapt the existing diagnostic criteria for MS in Russia, because it is necessary to take into account ethnic and genetic differences, national nutritional characteristics in the Russian population, lifestyle an...

ea0065p92 | Bone and calcium | SFEBES2019

Hypercalcaemia management in in-patients in a district general hospital

Ghosh Sukanya , Jude Edward

Background: Hypercalcaemia is a common finding in in-patients. Acute hypercalcaemia can be life-threatening; thus proper work-up is pivotal for correct assessment of underlying-cause and management. The European Hypercalcaemia Guidelines 2016 was used as reference.Aim: Study was undertaken to assess appropriateness in work-up, diagnosis and management of patients with hypercalcaemia according to European Guidelines.Methods: Patient...