Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep675 | Pituitary: basic and neuroendocrinology | ECE2015

Inferior petrosal sinus sampling in ACTH-dependent Cushing's syndrome: experience of a Tertiary Portuguese Hospital

Gomes Ana Coelho , Neto Lia Lucas , Carvalho Maria Raquel , Barreiros Eduardo , Aragues Jose Maria , Barreiros Luis , Campos Jorge , Mascarenhas Mario Rui

Introduction: Cushing’s disease (CD) is responsible for 80% of endogenous Cushing’s syndrome (CS). However, distinguishing the cause of ACTH-dependent CS – CD vs ectopic CS – can be extremely difficult. Bilateral inferior petrosal sinus sampling (IPSS) has the highest diagnostic accuracy in this evaluation.Objectives: The aims of this study were to determine the accuracy of bilateral IPSS in the differential diagnosis of ACTH-dependen...

ea0040p7 | (1) | ESEBEC2016

The genetic screening of RET proto-oncogene in Polish population during the past two decades

Oczko-Wojciechowska Małgorzata , Sromek Maria , Pawlaczek Agnieszka , Czetwertyńska Małgorzata , Kula Dorota , Żebracka-Gala Jadwiga , Rusinek Dagmara , Kowal Monika , Gubała Elżbieta , Szpak-Ulczok Sylwia , Gawlik Tomasz , Zub Renata , Tyszkiewicz Tomasz , Cyplińska Renata , Hasse-Lazar Kornelia , Wygoda Zbigniew , Krajewska Jolanta , Wiench Małgorzata , Dedecjus Marek , Jarzęb Barbara

Introduction: Gain of function mutations of RET protooncogene are associated with hereditary medullary thyrpoid cancer. There are mainly specific hot-spot RET gene mutations however they may differ between population.Aim of the study: In this study we report the prevalence of RET mutations in Polish population based on 20 years of experience of referral polish centers.Material and methods: RET ge...

ea0086pl1 | Clinical Endocrinology Trust Visiting Professor Lecture | SFEBES2022

Novel approaches for cushing’s medical management: Guidelines to clinical practice

Fleseriu Maria

A personalized patient treatment regimen for endogenous Cushing’s syndrome (CS) should be developed by a specialized multidisciplinary team, taking patient values and preferences into consideration. Comorbidities, which may compromise patient health and QoL need to be addressed, in many cases concomitant with or even before CS-specific treatments to restore eucortisolemia. Treatment of endogenous CS is initially primarily surgical and aims at complete resection of the und...

ea0086p83 | Metabolism, Obesity and Diabetes | SFEBES2022

Examining Smartphone Use During Mealtime and Its Association With Eating Disorders Among Adolescents

Balhara Maria

Background: 38% of teens use social media more than once an hour and 16% use it almost constantly (Rideout, 2018). Even so, the connection between smartphone use and nutrition and eating disorders is understudied and merits further study. Therefore, this study aims to examine the associations between smartphone use and eating disorders among adolescents.Methods: The study enrolled 325 participants aged 14-19 years in Florida, US, with 46% (n=150...

ea0063s23.1 | PCOS: can we personalise treatment? | ECE2019

Gut and brain axis

Insenser Maria

Microbiota plays a major role in health and disease in humans. Sex hormones influence the diversity and composition of the gut microbiota. Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age (6–20%). PCOS is characterized by the association of androgen excess with oligomenorrhea, anovulatory infertility, and increased metabolic risk factors. The study of the interaction between gut microbiota and sex hormones in PCOS coul...

ea0063gp228 | Adrenal and Neuroendocrine - Clinical (1) | ECE2019

Serine-threonine PAK1 as a novel common node for estrogen- and prolactin-dependent pathways in breast cancer

Diakonova Maria

Even though serine-threonine kinase PAK1 is activated by estrogen and plays an important role in breast cancer, the role of PAK1 in estrogen response is not fully understood. We have shown that estrogen activates PAK1 through both ERα and GPER1 plasma membrane receptors and that cytoplasmic Etk/Bmx directly phosphorylates Tyr153-PAK1 and activates PAK1 in response to estrogen. We have described a signaling complex composed of pTyr-PAK1, Etk, the heterotrimeric G-protein s...

ea0049ep867 | Clinical case reports - Pituitary/Adrenal | ECE2017

Acromegaly and pregnancy: case report

Khatib Maria

Introduction: Pregnancy in patients with acromegaly is a rare and challenging medical situation. Here in, we report a patient with acromegaly who presented to us in the 3rdtrimester of pregnancy after endoscopic transnasaltranssphenoidal radical excision of the tumor.Observation: A 36-year-old lady (Gravida 3 Parity 2 Live Birth 2), presented to our outpatient clinic on May 2007 forsuspicion of acromegaly. Clinical examination revealed acromeg...

ea0059mte5 | Non-surgical management of incurable thyroid cancer | SFEBES2018

Non-surgical management of incurable thyroid cancer

Alevizaki Maria

The majority of differentiated thyroid cancer (DTC) cases will be successfully treated with surgery usually (but not always) followed by radioiodine (RAI). The large majority have excellent prognosis. 10% of DTC may present disease progression: local relapse and/or distant metastases. 25–50% of these will slowly loose the capacity to take up radioiodine – RAI refractory cases. Further management includes loco-regional therapies such as surgical excision of lesions ca...

ea0059p064 | Clinical biochemistry | SFEBES2018

Gitelman Syndrome (GS) is a rare, salt-losing tubulopathy. Prevalence 1 in 40,000 higher in Asia. GS is an autosomal recessively inherited disease with a wide clinical spectrum, usually seen in adolescents and adults. It is reported that function loss develops in the sodium chloride cotransporter system in the distal renal tubule as the result of SLC12A3 gene mutation

Silveira Maria

GS, Patients have hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria together with normal blood pressure. Most of the patients are clinically asymptomatic, but some patients experience seizures, muscle weakness, cramps, episodic tetany, and paresthesia. The diagnosis is usually made based on clinical features and laboratory blood test. In this study we present a young patient with persistent hypokalaemia. She feels well in herself. She denies any symptoms of h...

ea0032pl3 | Changing character of thyroid cancer | ECE2013

Changing character of thyroid cancer

Alevizaki Maria

Thyroid cancer (DTC) is diagnosed more frequently these days due to increased awareness, wider availability of detection tools and, possibly, to true increasing incidence. The epidemiology of DTC is thus changing and more ‘innocent’ tumours are now being detected. The management of thyroid cancer and nodules is evolving and much progress has recently been made in the diagnosis and follow-up. Management guidelines have recently been published by scientific bodies and ...