Searchable abstracts of presentations at key conferences in endocrinology

ea0090p18 | Adrenal and Cardiovascular Endocrinology | ECE2023

AUTONOMOUS CORTISOL SECRETION AND BONE MINERAL DENSITY: IS SCREENING WORTHWHILE?

Saraiva Miguel , Palma Isabel

Introduction: Some studies have already described an association between mild autonomous cortisol secretion and poorer bone quality and increased risk of fracture. However, no consensus exists on this topic and currently there are no guidelines recommending bone status evaluation in patients suffering from this condition.Aims: To evaluate bone mineral density in patients diagnosed with autonomous cortisol secretion (ACS) and possible autonomous cortisol ...

ea0041ep12 | Adrenal cortex (to include Cushing's) | ECE2016

Nonfunctional adrenal incidentalomas and cardiometabolic risk

Ferreira Lia , Palma Isabel

Background: Incidentally discovered adrenal tumours have become a common clinical problem. The presence of an adrenal incidentalomas has been associated with an increase incidence of several cardiovascular risk factors. These abnormalities are more frequent in patients with clinical and subclinical hypercortisolism, nevertheless some studies have reported an association between nonfunctioning adrenal incidentalomas (NFAIs) with increased insulin resistance and cardiovascular r...

ea0090p400 | Environmental Endocrinology | ECE2023

Endocrine disrupting chemicals and thyroid hormone patterns during gestational periods: a systematic review approach

Forner Isabel , Baig Asma , Kortenkamp Andreas

The Hypothalamic Pituitary Thyroid (HPT) axis is well-known as a classic endocrine negative feedback loop: increased levels of thyroxine (T4) in the blood are associated with a reduction of thyroid stimulating hormone (TSH) production and vice versa. However, the thyroid hormone (TH) system is sensitive to alterations by a number of endocrine disrupting chemicals (EDCs). Intriguingly, exposure to specific EDCs can decrease the levels of T4 but this might be not followed by the...

ea0090p194 | Reproductive and Developmental Endocrinology | ECE2023

Masculinizing Hormone Therapy: What Happens to Estradiol and To Total, Free and Biovailable Testosterone?

Saraiva Miguel , Ferreira Lia , Palma Isabel

Introduction: Masculinizing Gender-Affirming Hormone Therapy (GAHT) generally aims to induce testosterone levels equivalent to those of cisgender men and to reduce estradiol levels. There are no studies about bioavailable testosterone in this population.Aims: To determine the variation of the serum levels of sexual hormones in transmasculine people under GAHT and study the correlations between them and with BMI.Methods: Longitudina...

ea0090ep660 | Environmental Endocrinology | ECE2023

Systematic evidence mapping of thyroid hormone patterns after exposure to endocrine disrupting chemicals in adult rodents

Baig Asma , Forner-Piquer Isabel , Kortenkamp Andreas

Certain endocrine disrupting chemicals (EDCs) are known to disrupt the thyroid hormone system. Thyroid hormone (TH) levels are physiologically regulated by the hypothalamic–pituitary–thyroid (HPT) axis, a tight feedback loop, whereby low levels of T4 stimulate an upregulation of TSH, and conversely if T4 levels are raised. Low levels of T4 (with chronic upregulation of TSH) can lead to thyroid hyperplasia – an outcome that is recognised by regulatory groups for ...

ea0035p312 | Clinical case reports Thyroid/Others | ECE2014

Diagnosis of neonatal diabetes mellitus in the mother through the detection of hyperglycemia in her child

Torres Isabel , Santos M Angeles , Castano Luis

Introduction: Neonatal diabetes mellitus (NDM) is a rare disease diagnosed within the first months of life that is usually permanent in 50% of cases. Heterozygous mutations of KCNJ11 and ABCC8 genes encoding the two Kir6.2 and SUR1 subunits of the b-cell ATP-dependent potassium channel have been associated with NDM, which is characterized by a successful response to sulfonylureas.Case report: We present a 32-year-old woman diagnosed wit...

ea0035p322 | Clinical case reports Thyroid/Others | ECE2014

Why obesity is multifactorial? Mixture of genetic predisposition, endocrine dysfunction and environmental factors: a case report

Tejera Cristina , Beato Pilar Isabel , Rodriguez Raquel

Introduction: Obesity prevalence is growing every year. In most cases, origin is exogenous, a mixture of sedentary and overeating. However, some patients are trend to develop obesity caused by their genetics and other illness.Case report: A 62-year-old women with diabetes type 2, anxiety and osteoporosis was remitted to our center for obesity. She had been obese since childhood, with very low level of activity and snacking trend. On physical examination ...

ea0022p647 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

A case of empty sella turcica and Cushing's disease

Goncalves Ana , Batista Fernando , do Carmo Isabel

Introduction: Cushing’s syndrome results from increased or aberrant expression of ACTH, CHR, or neuroendocrine receptors that leads to uncontrolled hypersecretion of cortisol. The most common cause is ACTH-secreting pituitary adenomas. Alternatively, the glucocorticoid excess may be due to adrenal neoplasia or to ectopic ACTH – secreting tumors. There are rare reports of patients with a meningioma secreting CRH presenting paraneoplasic Cushing’s syndrome.<p ...

ea0016p723 | Thyroid | ECE2008

Prevalence of antibodies to thyroid peroxidase (TPO) and postpartum thyroiditis (PPT) in a cohort of 1700 pregnant women with gestational diabetes mellitus (GDM)

Sharona Azriel , Isabel Camano , Antonio Garcia-Burguillo

The prevalence of antithyroid autoantibodies in pregnant women ranges between 6 and 10%, like in the general population. PPT, a syndrome of transient or permanent thyroid dysfunction occurring in the first year after delivery, is associated with the presence of TPO in gestation. The prevalence varies from 5 to 10%, with higher frequency in patients with DM1. The aim of this study is to estimate TPO frequency during gestation and its relationship with PPT in a group of women wi...

ea0014p356 | (1) | ECE2007

Outcomes of a fixed dose of 370 MBq of radioiodine in hyperthyroidism

Howat Isabel , Sawers Hilary , Sawers Stewart

In 1995 the Royal College of Physicians issued guidelines for the use of radioiodine in hyperthyroidism. They recommended administration of enough radioiodine to achieve euthyroidism, with acceptance of a moderate rate of hypothyroidism e.g. 15–20% at 2 years and 1–3% per annum thereafter. Guide activity was 400–550 MBq for standard hyperthyroidism (mainly Graves’ disease), at least 550 MBq for toxic multinodular goitre, and 300–500 MBq in toxic adenom...