Searchable abstracts of presentations at key conferences in endocrinology

ea0049n3.2 | (1) | ECE2017

Update on diet and lifestyle throughout lifespan to improve health – sexual hormones and bone, a close link throughout lifespan

Papadakis Georgios

Bone health is increasingly recognized as a crucial factor for quality of life. Osteoporosis, defined as bone impairment leading to an increased risk of fracture, is an important source of morbidity and even mortality in later life. Both male and female achieve the peak bone mass at around the age of 25 years. This peak is significantly lower in case of puberty and/or growth disorders, thus increasing the risk of osteoporosis later in life.Discussion: Ou...

ea0037ep478 | Diabetes (complications & therapy) | ECE2015

Changes in diabetes related quality of life and clinical outcomes in patients with type 2 diabetes, after initiation of injectable treatment

Georgas Georgios

In this study, we enrolled 123 patients with DM2 that accordingly to the based on evidence clinical judgment, needed injectable treatment for the achievement of good glycaemic control. There was not significant changes at the whole sample in anthropometrics, but there was increase in insulin treated subgroup and decrease in GLP1 treated subgroup. Glycaemic control was improved (P<0.001), without differences between detemir vs glargine subgroups, but with more impr...

ea0067gp6 | Poster Presentations | EYES2019

A review of myxedema madness: case reports of acute hypothyroidism presenting as psychosis

Syka Maria , Solias Georgios

Background: Hypothyroidism is a common disorder presenting with both somatic and psychiatric symptoms. Two cases of late onset psychosis are presented as an initial manifestation of myxedema.Case presentation: 1. An 80-year old woman who had no past medical history presented with auditory and persecutory hallucinations. During her hospital stay she was found to have a decreased level of consciousness (GCS:4), and a blood investigation showed the presence...

ea0041gp4 | Adrenal | ECE2016

The role of immunochemistry in the SDHx mutations in pheochromocytomas and paragangliomas

Angelousi Anna , Georgios Kyriakopoulos , Pavlos Constantinou , Georgios Zografos , Georgios Piaditis , Theodosia Xoreutaki , Dimitra Rontogianni , Gregory Kaltsas

Introduction: Early detection of succinate dehydrogenase complex (SDH) mutations in patients with pheochromocytoma and paragaglioma (PPC/PGL) has important implications as it is associated with increased risk for malignancy. The use of negative immunohistochemical (IHC) staining for SDH subunit B, D, A (SDHB/-D/-A) has been proposed as an indicator of SDHs mutation and as an effective substitute for the high-cost genetic screening of all of these genes.M...

ea0063p889 | Diabetes, Obesity and Metabolism 3 | ECE2019

Radiation-induced loss of glycemic control in a patient with refractory lymphoma

Adamidou Fotini , Komzia Paraskevi , Georgiou Thomas , Tsoutsas Georgios , Panagiotou Athanasios , Kita Marina

Introduction: PD-1 inhibitors are powerful disruptors of self- tolerance and autoimmune diabetes develops in up to 0.9% of patients. Lipodystrophic insulin reactions, although uncommon with human insulin analogs, are a recognized cause of impaired insulin delivery in patients on intensive insulin regimens. We describe a patient with resistant lymphoma and nivolumab-induced autoimmune diabetes, who suffered loss of glycemic control due to early radiation-induced subcutaneous fi...

ea0077oc4.6 | Adrenal and Cardiovascular | SFEBES2021

Glucocorticoids and the Vascular Molecular Clock: Implications in Vascular Function Control

Krilis Georgios , Bailey Matthew , Ivy Jessica

Glucocorticoids synchronise peripheral clocks with the master clock in the suprachiasmatic nucleus of the brain. In humans and mice, abnormal glucocorticoid rhythms induce blood pressure abnormalities accompanied by vascular dysfunction. The mechanisms of this remain unclear. We hypothesise that excessive activation of the glucocorticoid receptor (GR) disrupts circadian clock signalling, altering vascular function and inducing non-dipping blood pressure. We characterise the va...

ea0049ep618 | Diabetes therapy | ECE2017

Liraglutide restores the hyperglycemia-induced endothelial oxidative stress in vitro

Gougoura Sofia , Bargiota Alexandra , Koukoulis Georgios N

Introduction: Diabetes is characterised by increased oxidative stress and an insufficient antioxidant response, which are crucial for the initiation and progression of atherosclerosis. GLP-1 agonists, used for the treatment of diabetes, are considered as cardioprotective agents but under that concept, there are limited data on their ability to influence the endothelial antioxidant response.Methods: In order to answer this question we studied the influenc...

ea0056p511 | Diabetes therapy | ECE2018

Effects of opuntia ficus-indica plant extract ingestion on glucose and insulin plasma levels during oral glucose tolerance test

Christou Maria , Markozannes Georgios , Tigas Stelios

Background: Cladodes of the nopal opuntia streptacantha (prickly-pear cactus) have been traditionally used for the treatment of diabetes in Mexico. Limited data from studies in experimental animals and humans with prediabetes or type 2 diabetes (DM2), have shown promising antihyperglycemic effects using plant extracts of the streptacantha and ficus-indica opuntia species. The purpose of this study was to assess the effect of opuntia ficus-indica<...

ea0073yi10 | Young Investigator Awards | ECE2021

Placental expression of neurokinin B and its receptor NK3R is increased in women with polycystic ovary syndrome: results of a preliminary study

Markantes Georgios , Markatos Fotios , Georgopoulos Neoklis

BackgroundWomen with polycystic ovary syndrome (PCOS) are at increased risk of pregnancy complications and poor pregnancy outcomes. Defective placentation is among the proposed mechanisms involved. Altered neurokinin B (NKB) placental expression has been associated with several conditions characterized by placental dysfunction, such as pre-eclampsia and intra-uterine growth retardation. However, the expression of NKB and its receptors has not been studie...

ea0063p782 | Thyroid 2 | ECE2019

Polymorphisms G691S/S904S of RET proto-oncogene in a patient with sporadic medullary microcarcinoma

Boutzios Georgios , Papaoiconomou Eleni , Koukoulioti Eleni , Boronikolos Georgios , Spartalis Elefterios , Kykalos Stylianos , Tsourouflis Gerasimos

Introduction: Previous studies have shown that the G691S and S904S variants of RET proto-oncogene are associated with Multiple Endocrine Neoplasia (MEN) 2A syndrome and have a modifier effect on the age of onset. They are also associated with Papillary Thyroid Carcinoma and with Pheochromocytoma without Medullary Thyroid Carcinoma (MTC). Nevertheless, the influence of these polymorphisms on cases of sporadic MTC is still unclear. We present a patient with sporadic Med...