Searchable abstracts of presentations at key conferences in endocrinology

ea0022p796 | Thyroid | ECE2010

Echocardiographyc features in resistance to thyroid hormone

Lio Serafino , Danese Alfredo , Roiter Ignazio

Resistance to thyroid hormone (RTH) is a rare dominantly inherited condition of impaired tissue responsiveness to thyroid hormones. Different tissue may exhibit variable degree of resistance and clinical presentation probably depending on the heterogeneity of factors that modulate the isoform of thyroid hormone receptor (THR). The heart shows different isoforms of THR and few data is reported on the cardiac functionally effects of the phenotypic heterogeneity; echocardiography...

ea0063p912 | Diabetes, Obesity and Metabolism 3 | ECE2019

1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and lipid accumulation in liver cells: A role for epigenetic mechanisms?

Perez Francisca Salas , Martinez J Alfredo , Milagro Fermin I

Context: Vitamin D is a fat-soluble vitamin which requires the hydroxylation into 1,25-dihydroxyvitamin D (1,25-(OH)2D3) to be fully active. Vitamin D deficiency is a worldwide health problem associated to a wide range of acute and chronic diseases. On other hand, vitamin D supplementation has been proposed to reduced the risk of metabolic dysfunctions including obesity, type 2 diabetes and cardiovascular disease. Vitamin D interacts with the epigenetic m...

ea0063p914 | Diabetes, Obesity and Metabolism 3 | ECE2019

miRNAs-target genes, miRNA-lncRNA, and miRNA-small molecules interactions involved in metabolic diseases

Assmann Tais Silveira , Milagro Fermin I , Martinez J Alfredo

Context: Metabolic diseases affect millions of people in both developed and transition countries. In addition to genetic inheritance of risk alleles, emerging evidence has shown that these diseases are also linked to lifestyle and inherited epigenetic pattern interactions. The strong link between epigenetics and metabolism may offer attractive clinical applications to counteract and manage the escalating prevalence of metabolic diseases, such as obesity, type 2 diabetes mellit...

ea0037ep1247 | Clinical Cases–Thyroid/Other | ECE2015

Ectopic ACTH syndrome due to a pancreatic neuroendocrine tumour: a case report

Marti Juan , Zubillaga Elena , Bocangel Yenifer , Yoldi Alfredo

The ectopic secretion of corticotropin from no pituitary tumours causes ~10–20% of cases of Cushing’s syndrome. Enteropancreatic neuroendocrine carcinoma represents a rare cause of ectopic ACTH syndrome.Case: A 51 years-old woman without past medical history was admitted by gain weight, facial oedema 4 months previous. Physical examination: BP 167/124, cardiac rate 49 bpm, facial oedema, troncular obesity. No others abnormalities. Laboratory te...

ea0075p08 | Pituitary and neuroendocrinology | EYES2021

Indexes of chronic low-grade inflammation in different models of insulin-resistance: Evaluation of lipocalin-2 in metabolic sindrome, partial and total growth hormone deficiency

Bruno Carmine , Vergani Edoardo , Curro Diego , Pontecorvi Alfredo , Mancini Antonio

Lipocalin-2 (LCN2) is a glycoprotein synthetized by various cell types, including neutrophils, that acts as siderophores scavenger and play an important role in different chronic inflammatory processes. Metabolic Syndrome (MetS) and Adult Growth Hormone Deficiency (AGHD), both partial and total, are characterized by inflammatory features. The objectives of our cross-sectional study were: 1) to compare LCN2 levels in these clinical pictures; 2) to evaluate the relations between...

ea0075p10 | Pituitary and neuroendocrinology | EYES2021

Hormonal adjustment to metabolic derangement in adult Growth Hormone Deficiency: evaluation of Ghrelin and LEAP-2 serum level

Vergani Edoardo , Bruno Carmine , Curro Diego , Pontecorvi Alfredo , Mancini Antonio

Background: Ghrelin and its endogenous antagonist liver-expressed antimicrobial peptide-2 (LEAP-2) are involved in GH secretion, both acting on GSH-r1α, and regulation of glucose and lipids metabolism. Metabolic impairments are often accompanied by an upregulation of LEAP-2 expression, with a usual concomitant reduction in ghrelin secretion. Adult growth hormone deficiency (aGHD), characterized by weight gain, increased fat mass and insulin resistance, represent a conditi...

ea0081p229 | Thyroid | ECE2022

An innovative synthetic support for cytological and immunocytochemical assessment in cytologically indeterminate thyroid nodules. Feasibility study

Taccogna Silvia , Novizio Roberto , D'angelo Martina , Turrini Luca , Persichetti Agnese , Pontecorvi Alfredo , Papini Enrico , Guglielmi Rinaldo

Background: Fine needle aspiration (FNA) is the diagnostic procedure of choice in the evaluation of thyroid nodules. Nodules with indeterminate cytological categories, Tir3A and Tir3B according to Italian cytological classification, pose diagnostic challenges in clinical practice and are frequently submitted to diagnostic surgery. CytoFoam Core (CF) (Diapath, Martinengo, Italy) uses an absorbent foam device inserted into the needle hub to collect the cytological sample aspirat...

ea0081p738 | Thyroid | ECE2022

Predictors of associated autoimmune diseases in patients with Hashimoto′s thyroiditis.

Ruggeri Rosaria , Trunfio Francesca , Giuffrida Giuseppe , Trimarchi Francesco , Campenni Alfredo , Cannavo Salvatore

Background: Increased rates of autoimmune diseases (ADs) have been reported in association with Hashimoto′s thyroiditis (HT); however, the risk factors for coexisting ADs in HT patients have been poorly investigated.Objective: To evaluate the prevalence and factors associated with AD comorbidities in patients with HT.Materials and Methods: We recruited 687 patients (626 F and 61 M, mean age at diagnosis 39 ± 14.06 yr, F:...

ea0081ep81 | Adrenal and Cardiovascular Endocrinology | ECE2022

Percutaneous ethanol ablation of large adrenal tumor

Nebreda Inmaculada Venegas , Zunzunegui Nerea Egana , Ortega Cristina Elias , Achucarro Ane Amilibia , Arrieta Alfredo Yoldi

Introduction: Percutaneous ablation has been used over the years for the minimally invasive treatment of liver, kidney, thyroid and, although less frequent, adrenal cysts. We describe the case of a young patient with a large adrenal cyst treated with ethanol ablation, avoiding adrenalectomy.Clinical case: We present a 32-year-old woman who is referred to Endocrinology due to a 10 cm adrenal incidental finding in an MRI performed due to disc herniation. A...

ea0081ep152 | Calcium and Bone | ECE2022

Teriparatide for hypoparathyroidism after bariatric surgery

Maggio Ettore , Morgante Cesare , Ramunno Vittoria , Corsello Andrea , Cera Gianluca , Pontecorvi Alfredo , Corsello Salvatore Maria

Background: Hypoparathyroidism is an endocrine disorder characterized by hypocalcemia due to low levels of parathyroid hormone (PTH). Activated vitamin D (calcitriol) and calcium supplementation may be difficult in patients with malabsorption, as calcium requires an acid environment to dissolve. In this setting, subcutaneous administration of PTH analogues may be effective in reducing the dosage of oral calcium and vitamin D supplementation.Case report: ...