Endocrine Abstracts

Insulinoma causes fasting hypoglycemia due to inappropriate insulin secretion. The diagnosis of insulinoma is based on Whipple’s triad (1. symptoms precipitated by fasting with 2. associated blood sugars of 50 mg/dl or less and 3. relief of symptoms by glucose administration) during a supervised 72 h fasting test. After introducing reliable assays for measurement of insulin and proinsulin, there is an ongoing debate whether a 48 h fasting test is sufficient for diagnosis ...

Background: The H-syndrome is a recently described very rare monogenic systemic autoinflammatory autosomal-recessive genodermatosis with young onset of diabetes without evidence of autoimmunity. It is caused by mutations in the SLC29A3 gene, which encodes the equilibrative nucleoside transporter hENT3.Objectives: To study the clinical features and confirm the genetic diagnosis in a subject with young onset of diabetes.Subject and m...

Introduction: Osteotropic hormones demonstrate circadian rhythms which are integral to bone homeostasis. Sclerostin is a physiological inhibitor of bone formation. We have established that Sclerostin has a distinct circadian rhythm with a nocturnal peak. Analysis was performed to determine the relationship of Sclerostin levels to PTH, Calcium, Phosphate, βCTX and P1NP in healthy young men.Methods: Six healthy young men with normal BMD were admitted ...

Background: We and others have shown that ectopic lipids are flexible fuel stores in healthy subjects, in patients with type 1 diabetes or with GHD. IMCL are depleted by exercise and repleted by diet, whereas intrahepatocellular lipids (IHCL) are increased immediately after exercise. It is unclear whether the exercise-induced flexibility of IMCL and IHCL persists until 24 h and whether healthy subjects and patients with GHD behave differently.Methods: Ma...

Objective: Kisspeptin is hormone involved in the initiation and maintenance of fertility. Placenta is the major source of kisspeptin but its role during gestation is still matter of debate. Studies investigating kisspeptin levels during gestation in patients with diabetes and hypertension are lacking. Our aim was to prospectively evaluate kisspeptin levels in pregnant women with chronic diseases such as IDDM and H.Design and methods: Kisspeptin levels we...

Introduction: H. pylori infection has been related with extragastric diseases such as type 2 diabetes.Aim: to evaluate changes in carbohydrate metabolism induced by 75g oral glucose tolerance test (OGTT), before and after antibiotic eradication treatment in patients colonized by H. pylori compared to healthy controls.Materials and methods: A prospective case-control study. Biochemical parameters, carbohydrate profile, ghrelin and G...

Introduction: H. pylori infection has been related with diseases such as type 2 diabetes and metabolic syndrome.Objective: To evaluate changes in carbohydrates metabolism, lipid profile and intake regulating hormones induced by 75 g oral glucose tolerance test (OGTT), before and after antibiotic eradication treatment in patients colonized by H. pylori.Materials and methods: A prospective study of 40 non-diabetics patients were perf...

Aim: Overt hypothyroidism affects mostly women with an increased prevalence in individuals by age. Hypothyroidism is associated with accelerated atherosclerotic cardiovascular diseases, possibly caused by the higher incidence of hyperlipidemia, insulin resistance, hypertension which all are associated to hypothyroidism. Heart-type fatty acid binding protein (H-FABP) is specific for cardiomyocytes and a sensitive marker of myocardial injury. The purpose of this study is examini...

Introduction: H syndrome is a non-Langerhansian histiocytosis secondary to a mutation in the SLC29A3 gene encoding the nucleotide transport protein hENT3, It is a rare disease with a prevalence of 1 case 1,000,000 mainly characterized by hyperpigmentation, hypertrichosis and hepatosplenomegaly with endocrine manifestations including hypogonadism, short stature and insulin dependent diabetes mellitus. We report the case of a 20-year-old male who was admitted to our endocrinolog...

Background: ‘H’ syndrome is a rare autosomal recessive disorder characterised by hyperpigmentation, hypertrichosis, hepatosplenomegaly, hearing loss, hypogonadism, hyperglycaemia (insulin-dependent diabetes), hallux valgus and low height (short stature) and systemic inflammation. Caused by mutations in SLC29A3 gene located on chromosome 10q23 which encodes the human equilibrative nucleoside transporter 3 (hENT3). We report this case to highlight the rarity of the Syn...