Endocrine Abstracts

Introduction: Glucagonomas are rare functional pancreatic neuroendocrine tumours (p NETs), with an annual occurrence of 0.01 to 0.1 new cases per 100,000. Objective: We focused on presenting symptoms, primary’s size and location, presence of metastases, biomarkers at diagnosis, histology, response to first line treatment (clinical and biochemical), disease fee survival (DFS) and PFS (progression free survival). Methods: Eighteen pa...

Olfactory neuroblastoma (ONB) is a rare neuroendocrine tumour with a slow onset of symptoms, and classically a propensity for recurrence and a poor prognosis. Due to its rarity, there is no agreed standard therapy, but treatment will usually include surgical resection, adjuvant radiotherapy and/or chemotherapy. However, such tumours very often show positive uptake on somatostatin receptor radionuclide scanning, and selective use of peptide receptor radionuclide therapy (PRRT) ...

Background: Thyroxine-binding globulin (TBG) is the major human thyroid hormone transport protein. It is encoded by the SERPINA7 gene, located on the long arm of the X chromosome (Xq22.2). Inherited TBG abnormalities result in complete (TBG-CD) or partial (TBG-PD) TBG deficiency. We performed a comprehensive molecular analysis of the SERPINA7 gene in a Brazilian family with TBG-PD.Methods: Genomic DNA was extracted from the female proband, her father, di...

Introduction: Positive radiotracer uptake by the thyroid gland can occur in PET-CT. It’s meaning has led to conflicting results mainly resulting from small studies.Objective: We aim to present a large single institution consecutive case series.Material and methods: Observational, descriptive and retrospective study of the PET-CT scans performed between the years 2000–2017. We searched the word thyroid in the computer imag...

Background: Hypomagnesemia is common in patients with diabetes; possibly due to higher renal magnesium excretion in those patients. Hypomagnesemia seems to correlate with poor glycaemic control. The relationship between urinary magnesium (UMg) and glycaemic control is not known. We aimed to study the association between UMg and glycaemic control in a type 1 diabetes (T1D) pediatric population.Methods: Study of a pediatric population with T1D attending th...

Background: Pheochromocytomas (PHEO) are rare neuroendocrine tumors derived from chromaffin cells of the adrenal medulla. Catecholamins’ secretion is associated with a high risk of cardiovascular complications. Malignancy is rare, but still demands effective treatment. Metformin has been shown to have antiproliferative properties in several cancer cell lines, possibly related to its ability to inhibit cell proliferation pathways. Accordingly, we aimed to evaluate the effe...

Young people with Type 1 Diabetes Mellitus (T1DM) can achieve improved glycaemic control by using technology. T1DM technology is steadily improving however access to it remains variable across the UK. Those from ethnic minorities and deprived areas are less likely to access technology and more susceptible to developing complications of diabetes. Understanding the reasons for health inequalities is essential to facilitate use of available technology.Aim: ...

Children &Young people (CYP) with Diabetes Mellitus (DM) have increased rates of depression, anxiety, psychological distress and eating disorders than their healthy peers. Psychological factors and the patient’s health beliefs are important determinants of self-care behaviour. Randomised control trials have confirmed that Psychological interventions can significantly lead to improvement in measures of psychological well-being. Routine psychological support is advocate...

Objectives: To evaluate the usefulness of an Annual Review Questionnaire (ARQ) which was introduced as a clinical tool to assess Knowledge and Compliance of Children and Young People (CYP) with Type 1 diabetes with aspects of good clinical care as defined by National Institute of Clinical Excellence (NICE) guideline.Methods: All CYP with Type 1 diabetes, were expected to complete the ARQ as part of annual review. The questionnaire asked about compliance ...

In the UK, over 95% of children age 0–16 years presenting with diabetes have type 1 diabetes. Up to 25% of these present with DKA. Many present initially to GPs and it is important that children with symptoms of diabetes are referred urgently to Paediatric Diabetes Team.Aim: We carried out a survey of the current practise of GP’s when they suspect DM in a young person. The aim was to investigate whether they recognised the need for urgent refer...