Searchable abstracts of presentations at key conferences in endocrinology

ea0013p338 | Thyroid | SFEBES2007

The relative level and predictors of osteoporotic fracture in patients with treated thyroid dysfunction

Flynn Robert , Bonellie Sandra , Jung Roland , Morris Andrew , Macdonald Thomas , Leese Graham

Objectives: (1) to establish the relative level of osteoporotic fracture in the thyroid population compared to the general population, and (2) to establish whether osteoporotic fracture in patients receiving thyroxine was associated with plasma thyroid stimulating hormone (TSH) level or thyroxine dose.Method: A database of clinical information from subjects with treated thyroid disease was linked to morbidity records describing all in-patient episodes of...

ea0070aep790 | Reproductive and Developmental Endocrinology | ECE2020

Clinical evaluation and genetic analysis of patients affected by premature ovarian insufficiency: Identification and characterization of a new mutation of the BMP-15

Orsolini Francesca , Ferrarini Eleonora , Agretti Patrizia , De Marco Giuseppina , Di Cosmo Caterina , Benelli Elena , Fruzzetti Franca , Tonacchera Massimo

Background: Premature ovarian insufficiency (POI) is an ovarian defect characterized from primary or secondaryamenorrhea, high levels of FSH (> 25 UI/l) and low levels of estrogen, which occurs before age 40.Objective: The aim of the study was to evaluate the clinical features and genetic causes of a group of 68 patients with POI.Methods: We performed anamnestic and clinical evaluation, hormonal and autoimmunity assessment, pel...

ea0011p685 | Reproduction | ECE2006

Serum levels of PSA do not change in healthy pre-menopausal and in menopausal women, but are increased in subjects with polycystic ovary syndrome (PCOS)

Alessandro Burelli AB , Elisabetta Rineladi ER , Rossana Cionini RC , Elena Benelli EB , Aldo Pinchera AP , Enrico Pucci EP

Background/aims: Prostatic specific antigen (PSA) is the best prostatic tumor marker in man; Recently PSA has been detected in a variety of tissues and fluids in women and is considered a marker of hyperandrogenism. However no precise information are avaible about the physiology of PSA in females. The goal of this study was to assess serum concentrations of PSA in healthy pre-menopausal women (healthy pre-menopausal group) and menopausal women (menopause group) and compare the...

ea0011p691 | Reproduction | ECE2006

Oxidative stress, endothelial function, and arterial stiffness in young patients with polycystic ovary syndrome

Benelli E , Ghiadoni L , Giannini D , Rinaldi E , Plantinga Y , Taurino C , Burelli A , Bernini GP , Pinchera A , Pucci E

Polycystic Ovary Syndrome (PCOS) is currently believed a common endocrine-plurimetabolic disorder often associated to insulin resistance, diabetes mellitus, hypertension, hyperandrogenism, dyslipidemia and obesity, pathological conditions predisposing to high cardiovascular risk. Oxidative stress and endothelial dysfunction could represent early mechanisms of the cardiovascular risk in patients with PCOS. In order to confirm this hypothesis, 25 young (23.8±1.3 yr), over-w...

ea0011p692 | Reproduction | ECE2006

Aldosterone and renin plasma levels in young patients with polycystic ovary syndrome

Bernini GP , Bela S , Cionini R , Bardini M , Moretti A , Benelli E , Rinaldi E , Burelli A , Vitti P , Pucci E

Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age often associated with insulin resistance, diabetes mellitus, hyperandrogenism, dislipidemia, obesity and hypertension, pathological conditions predisposing to high cardiovascular risk. Insulin resistant subjects may have higher plasma renin activity and it is well known that aldosterone plays a well-recognized role in the pathophysiology of hypertension and in the development of...