Searchable abstracts of presentations at key conferences in endocrinology

ea0011p684 | Reproduction | ECE2006

Circadian changes in melatonin secretion and its relationship to gonadotropins in premenopausal women

Ianas O , Manda D , Calarasu R , Busu C , Campean D

Through its circadian pattern of melatonin (MT) secretion, the pineal gland helps to keep the internal physiology of animals in synchrony with the day-night cycle and with the annually changing seasons.Currently, however, the influence of MT on the human reproductive axis appears to be marginal and the available evidence supporting its physiological role is largely circumstantial; there is no clear consensus whether MT levels change during the menstrual ...

ea0011p24 | Bone | ECE2006

Effect of melatonin on gene expression and mineralization in mouse osteoblast culture

Manda D , Busu C , Ianas O , Stefanovici G , Calarasu R , Grigorie D , Dumitrache C

The physiological and neuroendocrine functions of the pineal gland hormone, melatonin and its therapeutic potential critically depend on the understanding of its target sites and its mechanism of action. There is evidence that melatonin promoted osteoblast differentiation and mineralization in MC3T3-E1 (mouse preosteoblast) and rat osteoblast-like osteosarcoma 17/2.8 cells. Our group set up an experimental model of mouse osteoblast culture. As a marker specific for osteoblast ...