Endocrine Abstracts

Through its circadian pattern of melatonin (MT) secretion, the pineal gland helps to keep the internal physiology of animals in synchrony with the day-night cycle and with the annually changing seasons.Currently, however, the influence of MT on the human reproductive axis appears to be marginal and the available evidence supporting its physiological role is largely circumstantial; there is no clear consensus whether MT levels change during the menstrual ...

Introduction: SOX2 is an early developmental transcription factor and a marker for pituitary progenitor cells.The study aimed to investigate if the pituitary adenomas with positive SOX2 immunoreactivity shows a different response to therapy as compared with controls.Patients and methods: We investigated 15 pituitary macroadenomas, eight with SOX2 immunoreactivity (SOX2+) and seven without (SOX2−) (controls); five were GH prod...