Endocrine Abstracts

Bile acids (BA) are cholesterol-derived molecules that are mostly known for their involvement in lipid digestion and absorption. Recent evidence recognizes them as metabolic integrators able to reduce body weight (BW), increase energy expenditure (EE) and improve glycemic control by activating their specific receptor, the Takeda G protein-coupled receptor 5 (TGR5) in peripheral organs. These outcomes have increased importance in the context of diet-induced obesity and associat...

The identification and characterisation of unique gene profiles expressed in specific adipose tissue depots around the body could provide novel insights on fat development.We report a comprehensive analysis of transcriptome from the five major (epicardial, pericardial, perirenal, sternal and omental) adipose depots from one week old sheep. This study also provides an integrated view of the preservation and differences between mitochondrial gene co-expres...

Introduction: DHEAS is weak androgen with specific role in human physiology illdefined. Various studies have implicated role of DHEAS in autoimmune arthritis including SLE and RA. Recently EULAR consensus statement has approved CSA (clinically significant arthralgia) for incipient RA.Methods and material: 34 follow up patients of primary hypothyroidism rated their symptom score on CSA (clinically suspect arthralgia) as given by EULAR(1) Their DHEAS level...