Endocrine Abstracts

Introduction: Diabetic nephropathy remains a major cause of morbidity and mortality for persons with diabetes mellitus. Globally, most patients with diabetes are in developing countries that do not have the resources or health infrastructure to provide universal renal replacement therapy. The ADA recommends that estimated glomerular filtration rate (eGFR) be calculated using serum creatinine for diabetics at least once a year.Objectives: To determine the...

Backround: Male hypogonadism is associated with an increased incidence of cardiovascular risk factors and approximately 25% of males suffering with coronary heart disease are hypogonadal. Few studies have assessed the impact of testosterone therapy on vascular function in hypogonadal individuals and none have investigated the weekly impact of gradually reducing testosterone concentrations on vasculature.Patients and Methods: 10 hypogonadal subjects (6 wi...

Backround: Recent research has heightened the controversy surrounding the effects of conventional hormone replacement therapy on cardiovascular risk, suggesting that use of HRT is associated with an increase in cardiovascular morbidity and mortality. Testosterone has also been associated with unfavourable cardiovascular parameters and the addition of testosterone to HRT may augment the risk of cardiovascular events in postmenopausal women.Aim: To elucida...

Introduction: Reduced creatinine clearance is related to an increased risk of diabetic foot ulcer development. Wound healing has been reported to be worse in diabetic patients with impaired kidney functions than general diabetic population. This study aimed to investigate the effect of creatinine clearance on the short term outcome of neuropathic diabetic foot ulcers.Materials and methods: Data from 147 neuropathic diabetic foot ulcer episodes were inclu...

Background: Directly measuring kidney function is time-consuming, expensive and impractical. Thus different formulas have been developed for estimating the glomerular filtration rate (eGFR) which provides a surrogate marker of clearance. The MDRD equation is commonly used to provide eGFR to clinicians. However, most product information suggests prescribing based on the estimated creatinine clearance (eCrCL) based on the Cockcroft–Gault (CG) formula. different equations ut...

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It results from various factors including erythropoietin (EPO) deficiency and inflammation. The aim of this study was to evaluate clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy. We investigated 95 anemic patients with type 2 diabetes mellitus and chronic kidney disease (stages 1–3). Glomerular filtration rate...

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It results from various factors including erythropoietin (EPO) deficiency and inflammation. The aim of this study was to evaluate clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy. We investigated 95 anemic patients with type 2 diabetes mellitus and chronic kidney disease (stages 1–3). Glomerular filtration rate...

Introduction: The prevalence of left ventricular hypertrophy (LVH) is high among patients with chronic kidney disease (CKD) and associated with a lower cardiac functional status, particularly in patients with diabetes mellitus (DM). The aim of the study was to estimate prevalence of LVH and to define factors influencing to development of LVH in patients with diabetic nephropathy (DN).Methods: patients with type 2 DM were studied - 22 males, 43 females, m...

Background: Diabetic nephropathy (DN) is a major cause of morbidity and mortality in type 1 diabetes (T1D) patients and associated with increased cardiovascular risk in type 2 diabetes (T2D) patients. Early detection of DN using neutrophil gelatinase-associated lipocalin (NGAL) assessment can help to reveal predisposed patients to its progression and to prevent progression of DN. Especially important it is in patients with normoalbuminuria.Aim: To determ...

Background: One of the basic genetic factors that impact on development of diabetic nephropathy is enhanced expression of vascular endothelial growth factor (VEGF).Objective: To study association between VEGF polymorphism +405 G/C and early stage of chronic kidney disease (CKD) in patients with impaired glycemic states.Materials and methods: 73 included patients were divided into three groups: group 1–26 patients with prediabe...