Searchable abstracts of presentations at key conferences in endocrinology

ea0085dmd1.3 | Diabetes Symposium 4 | BSPED2022

Developing an early stage treatment for diabetic retinopathy

Curtis Tim

Diabetic retinopathy is a serious complication of diabetes that can lead to vision loss and blindness. With the prevalence of diabetes rising in children, the number of young people at risk of developing diabetic retinopathy is expected to increase in the coming years. Current treatments for diabetic retinopathy only target the end-stages of the disease when significant retinal damage has already occurred. Thus, there remains an unmet medical need for new treatments, particula...

ea0085dmd1.3 | Diabetes Symposium 5 | BSPED2022

Developing an early stage treatment for diabetic retinopathy

Curtis Tim

Diabetic retinopathy is a serious complication of diabetes that can lead to vision loss and blindness. With the prevalence of diabetes rising in children, the number of young people at risk of developing diabetic retinopathy is expected to increase in the coming years. Current treatments for diabetic retinopathy only target the end-stages of the disease when significant retinal damage has already occurred. Thus, there remains an unmet medical need for new treatments, particula...

ea0005p17 | Clinical Case Reports | BES2003

A novel DAX-1 gene mutation with adrenal hypoplasia congenita, differing degrees of hypogonadism and decreased bone mineral density

Abdalla T , Owen A , Curtis A , Wilton A

Mutations of the DAX-1 gene cause X-linked adrenal hypoplasia congenita and hypogonadotrophic hypogonadism. Two half brothers (same mother, different fathers) were diagnosed as having Addison's aged14 years (brother A) and 7 years (brother B). Their mother had haemochromatosis being homozygous for the Cys 282 Tyr mutation of the HFE gene. Both had delayed pubertal development but defaulted from follow up. Brother A re-presented at 29 years of age with infertility. In view of t...

ea0077lb24 | Late Breaking | SFEBES2021

Hypopituitarism caused by Langerhans Cell Histiocytosis

Curtis Louise , Page Georgina , Richardson Tristan , Holt Helen

Langerhans Cell Histiocytosis is an inflammatory myeloid neoplasia caused by mutations of several genes in the MAPKinase (MAPK) pathway which can present in single or multiple sites. Our patient presented to her GP with several months of amenorrhoea, thirst, tiredness and 3 stone weight loss. She was previously fit and well, working, and married with children. Blood tests revealed panhypopituitarism with low 9am cortisol 117 nmol/l (133-537). Oestrogen and gonadotrophins were ...

ea0077lb28 | Late Breaking | SFEBES2021

A Heavy Heart

Curtis Louise , Richardson Tristan , Page Georgina , Holt Helen

Anabolic androgenic steroids (AAS) are class C drugs with adverse effects on health. Prevalence is increasing, often with a lack of awareness of the dangers. We present the case of a 33 year-old male with dilated cardiomyopathy and polycythaemia apparently due to AAS abuse over three years. The patient presented with five weeks of increasing breathlessness and chest tightness. Examination revealed evidence of congestive cardiac failure. Chest radiograph showed evidence of pulm...

ea0038p487 | Thyroid | SFEBES2015

A case of thyroid hormone resistance with unusually elevated free thyroxine

Curtis Louise , Page Georgina , Partridge Helen , Holt Helen , Richardson Tristan

A 21 year old Caucasian female with no known personal or family history of thyroid disease presented with several years history of anxiety and was found to have abnormal thyroid function tests. Results showed TSH: 1.8 mu/l (0.3–5.5), T4: 73 pmol/l (10–22), T3 12.3 pmol/l (3.1–6.8). Past medical history included chronic anxiety with no regular medications or nutritional supplements. There was no history of recent iodinated contrast administr...

ea0031p89 | Clinical practice/governance and case reports | SFEBES2013

Non islet cell tumour hypoglycaemia resistant to medical treatment

Rahman Mohammad , Wordsworth Simon , Curtis Gail , Wong Stephen

A 73 years old gentleman with a diagnosis of mesothelioma presented with symptoms typical of hypoglycaemia. Other than the expected abnormal chest signs there were no significant examination findings.Capillary glucose was unrecordable; lab testing confirmed serum glucose of 0.9 mmol/l. He had no history of diabetes mellitus or any medication that may induce hypoglycaemia. There was a slight rise in CRP and white cell count was elevated. There was no clin...

ea0011p554 | Growth and development | ECE2006

Developmental control of tissue deiodinases by cortisol in fetal sheep during late gestation

Forhead AJ , Curtis K , Kaptein E , Visser TJ , Fowden AL

Deiodinase enzymes have an important role in thyroid hormone metabolism. Type I 5′-monodeiodinase (D1) converts thyroxine (T4) to triiodothyronine (T3), while type III 5-monodeiodinase (D3) inactivates T3 and produces reverse-T3 (rT3) from T4. In fetal sheep, plasma T3 rises towards term in association with the prepartum cortisol surge. This study investigated the effect of cortisol on tissue de...

ea0059p076 | Clinical practice, governance & case reports | SFEBES2018

Outcomes of endoscopic surgical intervention for acromegaly – the Wessex experience

Curtis Louise , Mathad N , Chakraborty Aabir , Brewster Sarah , Millar Kate , Parsad Meenakshi , Al-Mrayat Ma'en

Background: Transsphenoidal surgery is the primary therapy in majority of Acromegaly patients with GH-secreting somatotroph adenomas. Reported outcomes of surgery show an initial remission rate of 40–50% for macroadenomas and >85% for microadenomas. Rates of hypopituitarism following endoscopic pituitary decompression vary between 5 and 25%. Invasion of cavernous sinus indicates the tumour is unlikely to be resectable.Methods: We audited the res...

ea0038p461 | Thyroid | SFEBES2015

Thyroxine administration: a challenging case

Loumpardia P , Wordsworth S , Curtis G , Bellamy C M , Waterfield N , Wong S P Y

Several preparations of thyroxine are available nowadays but is a great challenge for every clinician when the oral and intramuscular administration is failing and has to consider long term intravenous administration. This is a 42 years old lady who had a total thyroidectomy for Graves thyrotoxicosis. She commenced on multiple oral preparations of thyroxine and liothyroxine with no biochemical response. This is not a case of pseudomalabsorption as oral absorption studies of hi...