Endocrine Abstracts

Introduction: Diabetic nephropathy is a clinical syndrome characterized by overt proteinuria and decreased renal function in the course of diabetes mellitus. The earliest symptom is the presence of albuminuria, but a decrease in glomerular filtration rate(GFR) has been observed in patients without albuminuria. In our study, it was aimed to investigate the presence and prevalence of nonalbuminuric diabetic kidney disease observed in patients with type 2 diabetes, and to determi...

Although androgen insensitivity syndrome (AIS) is commonly suspected as a cause of a 46,XY disorder of sex development (DSD), only about half of these cases can be attributed to an inactivating mutation within the coding sequence (CDS) of the androgen receptor (AR) gene. This led to the hypothesis that disrupted AR activation in AIS may also be caused by a defect in a co-factor of AR-activity. However, so far mutations in AR co-factors leading to AIS have not been ide...