Endocrine Abstracts

Corticotropin Releasing Hormone (CRH) is the hypothalamic mediator of the stress response that ultimately results in increased release of glucocorticoid. CRH exerts its effects by binding to the CRH receptors 1 and 2 that belong to the family of the GPCRs. As we and others have shown in rodent and human tissues, peripherally expressed CRH is a potent proinflammatory factor. The immunomodulatory effects of CRH are exerted by its activation of the NF-κB DNA binding activity...

Introduction: Rare genetic overgrowth disorders are a group of conditions characterised by height and/or head circumference >2 S.D. above the mean for age and sex, learning disability, congenital anomalies, and in some cases childhood tumours. POD is a national cohort study that includes a next generation sequencing (NGS) panel of overgrowth genes. We present a new model for clinical confirmation of pathogenic variants identified by this research panel. Clin...

Objective: To test the reliability of the classic diabetic survey (DS) in the diagnosis of malnutrition in elderly patients with diabetes mellitus (DM).Patients and Methods: Analytical study of 55 patients aged over 65 years who were hospitalized in the Endocrinology Department. A DS was performed for all patients. The diagnosis of malnutrition was established according to the criteria proposed by the HAS 2021. Two subgroups were compared: G1 (n...

Introduction: Because of the increase of brain image explorations, the prevalence of pituitary tumours has increased a lot. Although most of them have an indolent behaviour, some behave aggressively, demanding a lot of resources for their management. Therefore, it is very important to identify them as soon as possible. The recent WHO 2017 classification of pituitary tumours gives insights into improving their identification using the immunostaining (IS) of transcription factor...