Searchable abstracts of presentations at key conferences in endocrinology

ea0019s30 | Polycystic ovarian syndrome (PCOS): when does it start, why and what to do about it? | SFEBES2009

Searching for genes in polycystic ovary syndrome

Franks Steve

There is strong evidence that genetic factors play an important part in the aetiology of PCOS1 and we have have proposed that PCOS has its origin in fetal life and that, in human females, exposure to excess androgen, at any stage from fetal development of the ovary to the onset of puberty, leads to many of the characteristic features of PCOS, including abnormalities of LH secretion and insulin resistance 2.In postnatal life the natu...

ea0044cmw4.1 | Workshop 4: How do I manage…(Supported by Endocrinology, Diabetes & Metabolism Case Reports) | SFEBES2016

How should I counsel a young woman with PCOS about fertility?

Franks Stephen

Fertility problems in women with PCOS are by no means inevitable. Indeed women who have symptoms of PCOS have at least one child just as often as those who do not have PCOS. But there is no doubt that women with PCOS who have oligo- or amenorrhoea are likely to require induction of ovulation and, in these circumstances, the sooner they seek the appropriate treatment for induction of ovulation, the better the chances of a timely pregnancy....

ea0059mc1.2 | Masterclass 1: PCOS | SFEBES2018

Polycystic ovary syndrome: management

Franks Stephen

Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory infertility, menstrual disturbances and hirsutism. PCOS is also associated with a metabolic disturbance characterised by hyperinsulinaemia and insulin resistance. Women with PCOS are at increased long-term risk of developing type 2 diabetes (T2DM) and carry a significant risk factor profile for cardiovascular disease. Obesity amplifies both reproductive and metabolic dysfunction. A growing body of evidence ...

ea0021d2 | (1) | SFEBES2009

This house believes that androgen replacement therapy, to get things going, should be offered to every hypogonadal woman

Franks Stephen

‘This house believes that androgen replacement therapy, to get things going, should be offered to every hypogonadal woman’.In opposing this motion, I shall review the advantages and disadvantages of androgen replacement therapy and draw attention to the folly of offering treatment to every hypogonadal women....

ea0021sig3.4 | PCOS Special Interest Group Session | SFEBES2009

Diagnosis and differential diagnosis of PCOS

Franks Stephen

Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory infertility, menstrual disturbances and hirsutism. In its classic form the presentation is of amenorrhoea or oligomenorrhoea associated with clinical and/or biochemical evidence of hyperandrogenism. However, it is clear that the spectrum of presenting symptoms of women with polycystic ovaries is wide, including anovulation without hirsutism (androgen levels are usually raised) and hirsutism with regular cyc...

ea0010s34 | Metabolic, reproductive and cosmetic aspects of PCOS | SFE2005

Reproductive aspects of polycystic ovary syndrome

Franks S

Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory infertility, and menstrual disturbances. The mechanism of anovulation is complex but the characteristic ovarian feature is arrest of antral follicles at 5–8 mm in diameter. Follicle arrest probably reflects the abnormal endocrine environment in which elevated LH and or hyperinsulinaemia (together with a relative deficiency of FSH) are important elements. However, recent studies also point to abnormali...

ea0007s13 | Actions of insulin in non-classical target issues | BES2004

Insulin action in the ovary

Franks S

The ovary may not be an obvious target tissue for insulin action but there is ample evidence to suggest that insulin affects glucose metabolism, steroidogenesis and cell growth/differentiation, and that these effects are relevant to both normal ovarian physiology and to disorders of ovarian function. Glucose uptake and glycolysis by granulosa cells - important for providing energy for the maturing oocyte are regulated by both insulin and gonadotrophins. In the human ovary, ins...

ea0004ds2 | Metabolic aspects of polycystic ovary syndrome | SFE2002

Metabolic aspects of polycystic ovary syndrome

Franks S

Hyperinsulinaemia and insulin resistance (IR) are well recognised features of polycystic ovary syndrome (PCOS). There is an interaction of BMI with ovarian morphology so that the more obese the subject with PCOS the greater the degree of IR compared with weight-matched controls. There is an associated dyslipidaemia and it has been suggested that women with PCOS are at increased risk of cardiovascular disease, although there is, as yet, little direct evidence for this. It is, h...

ea0002sp23 | A Legacy from Birth: a Focus on Turner's and Kallmanns | SFE2001

PARENTING OPTIONS FOR ADULTS WITH TURNER'S AND KALLMANN'S SYNDROMES

Franks S

Modern methods of induction of ovulation and assisted conception techniques have offered renewed hope for many infertile couples, including those with genetic causes of infertility. Turner's syndrome is, of course, characterised by primary ovarian failure and although spontaneous ovulation and conceptions have occasionally been reported, (usually in mosaic forms of Turner's) these events are rare and unpredictable. Attempts to induce ovulation are futile. The most realistic ch...