Endocrine Abstracts

Background: We analyzed in the vitamin D3 receptor gene (VDR) polymorphism can modulate therapeutic response of functional hypothalamic amenorrhea (FHA) patients to the estroprogestagen (EP) treatment.Material and methods: The study included 84 FHA girls and 50 controls. FHA patients underwent a 4-year sequential EP therapy with 17-β estradiol (2 mg from the 2nd to 25th day of the menstrual cycle) and didrogesterone (10 mg from the 16th to the 25th ...

The aim of this study was to verify if genetic factors influence the short- and long-term therapeutic response to estroprogestagen (EP) therapy implemented in girls with functional hypothalamic amenorrhea (FHA) in order to improve their bone mineral density (BMD). The study included 78 FHA girls who underwent a 4-year sequential EP therapy with 17β-estradiol and didrogesterone. Changes in the lumbar spine BMD were determined at the end of the therapy and 6 years after its...