Endocrine Abstracts

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Estrogen receptor alpha (ER) and progesterone receptor (PR) are widely used predictive and prognostic biomarkers in breast cancer. ER is also a well-established therapeutic target. A major unresolved clinical issue is the development of therapy resistance, especially to ER-targeted therapies. We, and others, have observed somatic ESR1 mutations in up to 40% of metastatic tumors obtained from women who have acquired resistance to endocrine therapies. The two most common mutatio...

Pre-gestational diabetics frequently rise to the challenge of pregnancy with remarkable improvements in diabetic control. Optimising pregnancy outcomes necessitates rigorous diabetes self-care, which is critically dependent on women’s capacity and the support they receive. The aim of this study was to identify self-reported drivers and inhibitors of self-care in pre-gestational diabetic pregnancies. The study was carried out at a tertiary referral maternity unit. Convenie...

The incidence of childhood thyrotoxicosis in the UK and Ireland is unknown. The commonest cause worldwide is Graves’ disease (60–90% of cases), with reported incidences varying from 0.79 (Denmark) to 6.5 (Hong Kong) per 100,000 pop./yr. Mean age at diagnosis is reported as 11.3 years with a F:M ratio of 5.5:1. Some countries have recently reported an increasing incidence.To ascertain the UK and Ireland incidence of childhood thyrotoxicosis and ...

Introduction: Adrenal incidentalomas are increasingly found in patients imaged for investigation. A service evaluation was undertaken to standardise care for these patients in line with the European Society of Endocrinology Guidelines.Aim: Standardise the care for patients with adrenal adenomas at Royal Liverpool University Hospital.Method: Retrospective review of 70 patients with adrenal incidentalomas over 2 years (January 2016&#...

Introduction: Adrenal incidentalomas are common occurrence with up to 3–10% of the general population who have imaging. Up to 20% of them may have autonomous cortisol secretion (ACS), a term that refers to biochemical evidence of excess cortisol, but without the overt cushing’s syndrome.Aim: Prevalence of ACS in our cohort of patients with adrenal incidentalomas and review their care.Method: Retrospective review of 70 pat...

Individuals considering research participation are provided with information but this is usually at the end of the process of engagement. Getting young people interested in research can be difficult, even more so when competing against a demanding school and social life that many young people lead. Working with a group of young people we produced a pilot website containing video and text material about diabetes and research that was designed to be appealing and informative.</p...

Case history: A 52 year-old lady was seen for further assessment of primary hyperparathyroidism (PHPT). She complained of intermittent symptoms of bloating but was otherwise asymptomatic. She was menopausal on hormone replacement therapy (HRT) and had started lithium for bipolar disorder 4 years ago. She had no known history of nephrolithiasis and no history of fractures. Her past medical history included Hodgkin’s lymphoma treated with chemotherapy 14 years ago, bipolar ...

Background: Several new gene mutations have been reported in recent years to be associated with a risk of familial phaeochromocytomas (PHAEOs). However, it is unclear as to whether extensive genetic testing is required in all patients (pts).Methods: Clinical data of consecutive patients operated for PHAEO over a decade in a tertiary referral centre were reviewed. Genetic screening was performed using a ten-gene panel: RET, VHL, SDHB, SDHD, SDHA, SDHC, SD...