Searchable abstracts of presentations at key conferences in endocrinology

ea0011p554 | Growth and development | ECE2006

Developmental control of tissue deiodinases by cortisol in fetal sheep during late gestation

Forhead AJ , Curtis K , Kaptein E , Visser TJ , Fowden AL

Deiodinase enzymes have an important role in thyroid hormone metabolism. Type I 5′-monodeiodinase (D1) converts thyroxine (T4) to triiodothyronine (T3), while type III 5-monodeiodinase (D3) inactivates T3 and produces reverse-T3 (rT3) from T4. In fetal sheep, plasma T3 rises towards term in association with the prepartum cortisol surge. This study investigated the effect of cortisol on tissue de...

ea0041gp159 | Pituitary - Clinical (1) | ECE2016

The partner perspective of the impact of pituitary disease: results from a focus group study

Andela Cornelie , Tiemensma Jitske , Kaptein Adrian , Scharloo Margreet , Pereira Alberto , Kamminga Noelle , Biermasz Nienke

Background: Patients with pituitary disease demonstrated Quality of Life (QoL) impairment. From other chronic diseases it is known that partners of patients also report impairments in QoL. Furthermore, it is observed that well-being of patients is associated with the well-being of their partners. To date, no data are available on the well-being of partners of patients with pituitary disease. Therefore, the aim of the present study was to explore well-being of partners of patie...

ea0037ep749 | Pituitary: clinical | ECE2015

The development and validation of a new burden and needs assessment questionnaire for patients with pituitary diseases: the BNQ-pituitary

Andela Cornelie , Scharloo Margreet , Ramondt Steven , Tiemensma Jitske , Kaptein Ad , Pereira Alberto , Kamminga Noelle , Biermasz Nienke

Background: An increasing number of studies assess quality of life (QoL) in patients with pituitary diseases. At present, available disease-specific QoL questionnaires do not completely cover the patient perspective of QoL. Furthermore, there are no disease-specific questionnaires available which inventories patient’s needs for help for impairments in QoL.Objective: To develop and validate a disease-specific QoL questionnaire for patients with pitui...

ea0026p196 | Pituitary | ECE2011

Coping strategies in patients after treatment for functioning or non-functioning pituitary adenomas

Tiemensma J , Kaptein A A , Pereira A M , Smit J W A , Romijn J A , Biermasz N R

Context and objective: Coping strategies may affect quality of life (QoL), which is decreased in patients after treatment for Cushing’s disease, acromegaly, or non-functioning macroadenomas (NFMA). We aimed to explore coping strategies in these patients, since this has never been done before.Design: A cross sectional study.Subjects: We included patients treated for Cushing’s disease (n=42), for acromegaly (n...

ea0026p215 | Pituitary | ECE2011

Illness perceptions, quality of life and self-reported physical symptoms in patients after long-term remission of Cushing’s syndrome

Tiemensma J , Kaptein A A , Pereira A M , Smit J W A , Romijn J A , Biermasz N R

Context and objective: Illness perceptions pertain the pattern of beliefs patients develop about their illness. These views are determinants of behavior directed at the illness. Illness perceptions are determinants of quality of life (QoL). QoL remains impaired in patients after treatment of endogenous hypercortisolism, however, illness perceptions were never studied in these patients. The objective of the current study was to explore illness perceptions and its relation with ...

ea0025p267 | Reproduction | SFEBES2011

Placental iodothyronine deiodinase activity across the placental bed in normotensive (NT) and pre-eclamptic (PE) pregnancies.

Kurlak Lesia , Mistry Hiten , Kaptein Ellen , Visser Theo , Pipkin Fiona Broughton

Background: PE affects ~2% of pregnancies and is associated with generalised endothelial cell dysfunction. Antioxidant selenoproteins may limit such effects. Serum selenium is lower in mothers and babies affected by PE and associated with lower activity of the selenoprotein glutathione peroxidases. Other selenoproteins, the iodothyronine deiodinases (IDs; D2 and D3) regulate fetal thyroid hormone synthesis. The IDs utilise selenium preferentially; we have reported similar trii...