Searchable abstracts of presentations at key conferences in endocrinology

ea0069p36 | Poster Presentations | SFENCC2020

Somatostatin analogue therapy in a patient with von Hippel-Lindau Disease and multiple pancreatic neuroendocrine tumours

Wallner Marie , Karunakaran Vanitha , Bano Gul

Case report: Von Hippel-Lindau Disease (VHL) is an autosomal-dominant disease with almost complete penetrance, characterized by the development of several types of neoplasia. Non-functioning pancreatic neuroendocrine tumours (pNETs) are part of the syndrome in up to 16% of the patients. A 36 year old female with a known diagnosis of VHL (Mutation exon 3) was under surveillance. She had previous surgeries twice for haemangioblastomas, and an adrenalectomy for phaeochromocytoma ...

ea0015p335 | Thyroid | SFEBES2008

Cholestasis induced by carbimazole: a case report

Vithian Karunakaran , Vithian Sivamala , Skelly Robert

An 85-year-old lady presented to hospital with fast atrial fibrillation and had some signs of pulmonary congestion. Her admission blood tests were normal apart from a raised urea. Her liver function tests on admission were normal (AST 26 ALP 99). Thyroid function tests showed that she was thyrotoxic with fT4 42 and TSH<0.03. Her TPO antibodies were negative. She was started on carbimazole 20 mg od.Repeat liver function tests showed that her GGT and a...

ea0055oc10 | National Clinical Cases | SFEEU2018

An unexpected VIP

Margari Niki , Tufton Nicola , Vithian Karunakaran , Mehta Sampi , Akker Scott

Case history: A 69-year-old Caucasian male presented with persistent abdominal pain and was found to have a large right adrenal mass on CT. Interestingly his family history revealed that his daughter had been treated for Cushing’s disease. He was normotensive and denied classical symptoms of catecholamine excess. He had exertional dyspnoea in keeping with COPD. Subsequent tests were consistent with a secretory phaeochromocytoma and urine normetadrenaline 85,671 nmol/day (...

ea0037ep1317 | Clinical Cases–Thyroid/Other | ECE2015

Stress cardiomyopathy following radioactive iodine therapy: a case report

Dimakopoulou Anastasia , Vithian Karunakaran , Ganon David , Harkness Alan

A 55-year-old female presented to the Endocrine Clinic with Graves’ disease which was treated with carbimazole for 18 months. Her initial symptoms were facial sweating and dry lips on background of a multinodular goitre confirmed on thyroid ultrasound. TSH was <0.01 mU/l, free T4 was 42.2, and free T3 18 pmol/l. Thyrotoxicosis recurred in an attempt to taper down the dose of carbimazole and a decision was made to proceed with radioactive iodine t...

ea0034p105 | Clinical practice/governance and case reports | SFEBES2014

Phaeochromocytomas and paragangliomas: a 20 year experience

Velusamy Anand , Karunakaran Vanitha , Kirtchuk David , Quin John

Phaeochromocytomas and paragangliomas account for about 0.1% of cases of persistent hypertension. Only 50% of these are being diagnosed as symptoms are often paroxysmal.We report a retrospective data analysis on 16 random patients (age 24–71 years, mean 51) diagnosed and treated for phaeochromocytoma and paraganglioma in our centre over the past 20 years. Symptom duration was 6 weeks to 15 years with female preponderance 2:1 (69 vs 31% in males). Sy...

ea0011p656 | Reproduction | ECE2006

Standardisation and validation of a sensitive enzymeimmunoassay procedure to estimate 13,14-dihydro-15-keto-PGF (PGFM) in mithun (Bos frontalis) plasma

Mishra DP , Dhali A , Mech A , Karunakaran M , Choudhury H , Rajkhowa C

Mithun (Bos frontalis), a free-range domesticated ungulate, reared primarily for beef and occasionally for milk, is mainly distributed in the South-East Asia. Much scientific reports on reproductive-endocrinology in this species are not available at present. The current study was designed to standardise and validate a simple, sensitive and direct enzymeimmunoassay (EIA) on microtitre plates using second antibody coating technique to determine 13,14-dihydro-15-keto PGF<s...

ea0044p54 | Bone and Calcium | SFEBES2016

Surgical management of primary hyperparathyroidism in East Sussex Healthcare NHS Trust (retrospective audit of patients had parathyroidectomy over 2 years in East Sussex NHS Trust)

Karunakaran Vanitha , Ahmad Shakeel , Ali Simeen , Govindan Rajesh , Kirkland Paul , Sathiskumar Periasamy

Retrospective audit of Patients had Parathyroidectomy over 2 years in East Sussex NHS trust; 73 patients had Parathyroid surgery for Primary hyperparathyroidism during this period. We have collected the data using case notes and hospital electronic records. Fifty-six patients were females and 17 were Males. Ninety-three per cent of patients were more than 50 years old. Common presenting symptoms were Lethargy (51%), bone pain (44%) and other symptoms were polyuria, polydipsia....

ea0081p175 | Pituitary and Neuroendocrinology | ECE2022

Low post-operative cortisol after TSS for pituitary surgery predicts short term but not long term remission

Karunakaran Vanitha , Okasha Mohamed , W Thomas Nick , Barazi Sinan , Maratos Eleni , C Whitelaw Benjamin , Gilbert Jackie , V Carroll Paul , Shapey Jonathan , J B Aylwin Simon

Background: It is generally accepted that a post-operative cortisol of <50 nmol/l is a good predictor of long-term remission following trans-sphenoidal surgery (TSS).Aim: We wished to determine the rate of late recurrence and need for consequent intervention in patients who had initial biochemical remission after TSS for pituitary dependent Cushing’s.Methods: We performed a retrospective analysis of our patients who underw...