Endocrine Abstracts

Background: The aim of the present study was to represent our summarized results of plasma endothelin-1 (ET-1) level determined in some endocrine diseases like diabetes, hyper- and hypothyroidism, Cushing’s disease, acromegaly and male hypogonadism in which the existence of endothelial dysfunction and increased cardiovascular risk is proved.Patients and results: In patients with type 2 diabetes (n=34), plasma ET-1 (0.9±0.17 pmol/l) corre...

Endothelin-1 has various paracrine and endocrine effects on the male reproductive system. It is supposed that the testosterone is probably responsible for the higher endothelin-1 levels in males and this may be related with the enhanced cardiovascular risk in males of reproductive age. In order to study in more detail the relationship between endothelin-1 and testosterone, we have studied 37 male patients with various forms of hypogonadism (14 with hypergonadotrophic hypogonad...

Introduction: Midnight salivary cortisol measurement (MSC) has been recently introduced as a diagnostic test for hypercortisolism. The aim of our study was to compare the diagnostic value of two methods of screening for Cushnig’s syndrome (CS): MSC and 24-h urinary free cortisol (UFC), wildely accepted as a ‘gold standard’ for this diagnosis.Patients and methods: Three groups were studied: 30 patients with CS (mean age±S.D.</sm...

Introduction: Low endogenous testosterone levels are related to the metabolic syndrome /MS/ and diabetes type 2 in middle-aged and elderly men, but little is known about interrelations testosterone-insulin in younger hyperinsulinemic men. Recent studies have shown that the night melatonin in males with hypogonadotropic hypogonadism is significantly higher in comparison with the healthy men, while it is significantly reduced in patients with hypergonadotropic hypogonadism. Howe...

Background: Diabetes and prediabetes have become major public health problems in recent decades.Objectives: The aim of the study was to evaluate the predictive value of risk factors on progression from prediabetes to type 2 diabetes.Materials and methods: A total of 383 subjects (213 females, 170 males), mean age 51.93±13.47 years and mean BMI 29.11±5.3 kg/m2, divided in three groups – 147 with normal gluc...

Introduction: Apart from being individually associated with cardiometabolic health, Vitamin D and growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis are reported to interplay, with a positive correlation between IGF-1 and 25-hydroxyvitamin D (25(OH)D). These findings raise questions about the role of vitamin D for the adverse cardiovascular (CV) risk profile in hyposomatotropism. Thus, the aim of our study was to investigate the association between 25(OH)D and metabol...

Introduction: Vitamin D and growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis are reported to interplay at both endocrine and paracrine levels, with a positive correlation between IGF-1 and 25-hydroxyvitamin D (25(OH)D) in healthy subjects. Hyposomatotropism is among the conditions predisposing to lower vitamin D status due to several direct and indirect mechanisms. Thus, the aim of our study was to evaluate vitamin D status in a representative sample of adults with ...

Aim: The present study aimed to compare the androgen levels in men with obesity, metabolic syndrome /MS/ and healthy normal – weight controls.Materials and methods: Eighty-six males (mean age 29.65±8.57 /18–50/) were investigated. 31 of them were healthy (mean BMI – 23.66±1.97); 22 were with simple obesity (mean BMI – 32.79±7.16) and 33 (mean BMI – 35.78±8.71) were with overt metabolic syndrome /MS/ according ...

Recently was established, that in the ovary Anti-Müllerian hormone (AMH) is produced by the granulose cells and correlated with the count of small antral follicles. As AMH is largely expressed throughout folliculogenesis, it is considered that the serum levels of AMH may represent both the quantity and quality of the ovarian follicle pool. To determine the changes of AMH in women with polycystic ovary syndrome (PCOS) we have studied 22 patients with this disorder and comp...

Until recently primary aldosteronism /PA/ was thought to be rare, accounting for no more than 0.05–2% of the hypertensive patients. Studies published in the last decade demonstrate that primary hyperaldosteronism is a much more common cause of secondary hypertension than was previously thought, accounting for as many as 5% to 25% of hypertensives in some series. For the present, there are no data concerning the prevalence of PA in Bulgaria which determined the realization...