Searchable abstracts of presentations at key conferences in endocrinology

ea0056p133 | Endocrine tumours and neoplasia | ECE2018

Presence and functional role of KiSS/KiSS-R system in pancreatic neuroendocrine tumors (panNETs) and its relationship with clinical features and tumor behavior

Alors-Perez Emilia , Pedraza-Arevalo Sergio , Herrera-Martinez Aura , Diaz-Perez Angel J , Caro Teresa , Serrano-Blanch Raquel , Sanchez-Sanchez Rafael , Galvez-Moreno Maria Angeles , Castano-Fuentes Justo P , Luque Raul M , Martinez-Fuentes Antonio J

Pancreatic neuroendocrine tumors (panNETs) are the second most common neoplasm of the pancreas. panNETs arise from cells of the pancreatic islets and comprise a diverse and heterogeneous group of neoplasms. This hampers their systematic study, and the identification of common molecular signatures that might facilitate a better diagnosis of the disease, and the development of efficient therapeutic approaches. Indeed, there are no clinical, biochemical, anatomopathological, immu...

ea0063p313 | Reproductive Endocrinology 1 | ECE2019

A novel rare case of normosmic congenital hypogonadotropic hypogonadism associating a GnRHR and a KISS1R variants

Valdes-Socin Hernan , Libioulle Cecile , Debray Francois-Guillaume , Dideberg Vinciane , Bours Vincent , Beckers Albert

Case report: We describe a 28 years old male patient born in IRAK, beeing referred to us because of suspicion of congenital hypogonadism. The patient was 1.86 m tall and 1.97 spam arm and he was no anosmic. He had a 2.5 cm micropenis, and a bilateral reduced testicular volume (3.6 and 3.9 ml). LH 1.7 U/l (2–10), FSH 3.1 U/l (1–8), testosterone 0.7 mmol/l, estradiol <12 ng/l, inhibine B 54 ng/l (105–439) Pituitary MRI was normal.Genetic...

ea0056gp217 | Reproduction | ECE2018

The first Belgian series of 56 patients with congenital hypogonadotropic hypogonadism (CHH): genetic and brain abnormalities

Valdes-Socin Hernan , Libioulle Cecile , Harvengt Julie , Pintiaux Axelle , Jonas Christelle , Parent Anne Simone , Geenen Vincent , Corman Vincianne , Debray Francois Guillaume , Dideberg Vincianne , T'Sjoen Guy , De Leerner Anne , Beckers Dominique , Destree Anne , Roland Dominique , Lederer Damien , Boscolo Marina , Bours Vincent , Maiter Dominique , Beckers Albert

Introduction: CHH is a genetic syndrome that combines reproductive and brain abnormalities. The brain phenotype has been incompletely characterized. We aimed to study neuroradiological and genetic features in this first Belgian series of patients with CHH.Methods: A series of 56 adult patients (48 males, 8 females) presenting with CHH was investigated for a panel of 16 genes related to hypogonadotropic hypogonadism by next generation sequencing on a MiSe...