Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1196 | Obesity | ICEECE2012

Prediabetes in adult GH deficiency is associated with a substantial reduction in serum and adipose tissue expression levels of zinc-α2-glycoprotein

Balaz M. , Ukropcova B. , Kurdiova T. , Penesova A. , Skyba P. , Vlcek M. , Belan V. , Klimes I. , Payer J. , Imrich R. , Smith S. , Tkacova R. , Gasperikova D. , Ukropec J.

Adult GH deficiency (GHD) is associated with prediabetes and low levels of GH are found in obesity. We hypothesized that zinc-α2-glycoprotein (ZAG), a novel adipokine reduced in obesity, is regulated by GH. ZAG serum and adipose tissue expression were measured in three study populations: i) cachectic (BMI=19.3±0.5 kg/m2), lean/overweight (BMI=26.0±0.5 kg/m2) and obese (BMI=36.0±1.6 kg/m2) patients with chronic obstructive pu...

ea0014p22 | (1) | ECE2007

Screening of 120 adipokines in subcutaneous adipose tissue of patients with growth hormone deficiency reveals changed protein levels

Gasperikova Daniela , Ukropec Jozef , Penesova Adela , Sell Henrike , Skopkova Martina , Vlcek Miroslav , Radikova Zofia , Koska Juraj , Belan Vitazoslav , Pura Mikulas , Vanuga Peter , Payer Juraj , Eckel Jurgen , Klimes Iwar

The role of adipokines and inflammatory cytokines of adipose tissue for development of the growth hormone deficiency (GHD)-related metabolic derangements has not yet been completely understood. Therefore, we screened the protein level of 120 adipokines in subcutaneous adipose tissue (ScAT) of patients with GHD in adulthood.Subjects and methods: Sixteen GHD (10M/6F) with BMI 27±1.0 kg/m2, age 30±2 yrs and sixteen controls matched for ...

ea0011p241 | Cytokines and growth factors | ECE2006

Effect of growth hormone deficiency in adults on insulin action and gene expression of selected adipokines in subcutaneous adipose tissue

Penesova A , Skopkova M , Pura M , Vlcek M , Radikova Z , Vorzakova I , Tajtakova M , Vanuga P , Belan V , Koska J , Payer J , Klimes I , Gasperikova D

Growth hormone deficiency (GHD) in adults seems to predispose to insulin resistance (IR). Development of GHD related IR could be associated with adipose tissue (AT) derived signals. To investigate the nature of this pathological regulation we 1) measured gene expressions for leptin, adiponectin, TNFalpha, IL-6, 11beta HSD1, SREBP, PPARgamma in the AT of untreated GHD adults, and 2) assessed effect of euglycemic hyperinsulinemia (HI) at the gene level.Met...

ea0035p884 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Register of sellar tumors: RESET: diagnostics and therapy of acromegaly in Czech and Slovak Republics

Hana Vaclav , Svancara Jan , Bandurova Lubomira , Brabec Petr , Cap Jan , Durovcova Viktoria , Dvorakova Eva , Hana Vaclav , Jarkovska Zuzana , Kentos Peter , Klimes Daniel , Krcma Michal , Krsek Michal , Lazurova Ivica , Olsovska Vera , Podoba Jan , Pura Mikulas , Sasikova Michaela , Stary Karel , Strenkova Jana , Siprova Helena , Steno Juraj , Trejbalova Ludmila , Vanuga Peter , Wagnerova Hedviga , Weiss Vladimir , Zeman Dalibor , Dusek Ladislav , Marek Josef

Acromegaly is usually diagnosed after several years of duration. The multimodal therapy – surgery, radiotherpy, pharmacotherapy – is necessary in the majority of patients. Register of sellar tumors (RESET) collecting data of patients from eight tertiary centers in the Czech and Slovak Republics since the year 2000 was established in 2008.Aim of analysis: Evaluation of diagnostics of acromegaly and effectiveness of its treatment in a daily pract...

ea0022p553 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Efficacy of acromegaly treatment in six Czech and Slovak tertiary centers: first analysis of patient registry RESET (Registry of Sellar Tumors)

Hana Vaclav , Bandurova L , Brabec P , Cap J , Durovcova V , Hana V , Jarkovska Z , Kentos P , Klapka R , Klimasova K , Klimes D , Krsek M , Lazurova I , Olsovska V , Podoba J , Pura M , Siprova H , Steno J , Sticha M , Trejbalova L , Vanuga P , Wagnerova H , Weiss V , Zeman D , Dusek L , Marek J

Acromegaly is frequently diagnosed late and pituitary macroadenoma is revealed in the majority of patients. Treatment usually needs combination of several treatment modalities to suppress the disease activity. Efficacy of our treatment of acromegaly was not analysed till now.Aim: First analysis of the diagnostics of acromegaly, efficacy of treatment, its complications and status of acromegaly patients in six tertiary referral centers in the Czech Republi...