Searchable abstracts of presentations at key conferences in endocrinology

ea0035p158 | Calcium and Vitamin D metabolism | ECE2014

Evaluation of the relationship between vitamin D concentration and selected clinical and biochemical features in women with polycystic ovary syndrome

Szymonek Monika , Kowalska Aldona

Introduction: Vitamin D deficiency (25OHD) is common in women with polycystic ovary syndrome (PCOS). 67–85% of female patients with PCOS have low concentration level of 25OHD (<20 ng/ml). It is believed that low concentration levels of 25OHD may exacerbate the symptoms of PCOS.Aim: The aim of the study was to evaluate the concentration of 25OHD in women diagnosed with PCOS and the analysis of the relationship between 25OHD concentration and such...

ea0035p1067 | Thyroid (non-cancer) | ECE2014

Successful preoperative treatment of toxic nodular goiter patient with agranulocytosis using plasmapheresis

Trybek Tomasz , Kowalska Aldona

Agranulocytosis is an uncommon but very serious complication during treatment with thyrostatic. In case of severe hyperthyroidism removal of circulating thyroid hormones by plasmapheresis may be an effective therapeutic option.We present the therapeutic difficulties and successful treatment with preoperative plasmapheresis in 63-year-old female patient with severe hyperthyroidism in the course of toxic nodular goiter and agranulocytosis, which occurred a...

ea0020p316 | Clinical case reports and clinical reports | ECE2009

Malignant pheochromocytoma with brain metastases and coexisting meningioma: case report

Kowalska Aldona , Lizis-Kolus Katarzyna

Introduction: Pheochromocytoma is usually benign neuroendocrine tumor arising from chromaffin cells. Malignant tumors which account for 5–26% mainly metastize to bones, lungs, liver, but very rarely to brain. The coexistence of pheochromocytoma with brain meningioma may hinder the diagnosis.Aim: The aim of this study is to present the case of a malignant pheochromocytoma female with brain metastases and coexisting meningioma.C...

ea0081p93 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Determination of serum and cord blood vitamin D status in women in twin pregnancies using liquid chromatography-tandem mass spectrometry – a preliminary results

Zgliczynska Magdalena , Szymusik Iwona , Kowalski Konrad , Ostrowska Magdalena , Kosinska-Kaczynska Katarzyna

Objective: Vitamin D has a pleiotropic effect on the human body. Besides its classical function as a regulator of calcium and phosphorus metabolism, it influences the secretion of other hormones, modulates the immune response and regulates cell proliferation and differentiation. Because women in twin pregnancies have higher metabolic needs, it can be expected that they might have higher risk of vitamin D deficiency.Aim of the study and method: The aim is...

ea0070ep360 | Pituitary and Neuroendocrinology | ECE2020

Carcinoid crisis after peptide receptor radionuclide therapy in patient with midgut neuroendocrine tumor.

Brodowska-Kania Dorota , Saracyn Marek , Kolodziej Maciej , Kowalski Lukasz , Kaminski Grzegorz

Background: Carcinoid crisis (CC) may rarely occur as a complication of general anesthesia/surgery or peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumor (NET). The incidence of CC as a complication of PRRT is underestimated and comes to 10% of all radioisotope therapies. Progressive organ dysfunction, decrease or increase in blood pressure SBP <80 mmHg or >180 mmHg, unexplained tachyarrhythmia with heart rate >120/ min, bronchoconstr...

ea0031p290 | Pituitary | SFEBES2013

BMP4 induces terminal differentiation of primary trophoblast cells and increases chorionic gonadotrophin secretion

Cabrera-Shaarp Victoria , Richardson Stephanie , Kowalski Alycia , Antczak Doug , Mukherjee Abir , Mestre Amanda de

Objective: Chorionic gonadotrophin (CG) is a hormone induced during terminal differentiation of trophoblast cells that significantly influences pregnancy outcome. The TGFβ superfamily SMAD2/3 pathway regulates placental function but the activity of the alternative pathway through SMAD1/5/8 in the placenta is unknown. This study investigated the role of BMP4 signalling through SMAD1/5 in terminal differentiation of primary chorionic gonadotrophin-secreting trophoblast cell...

ea0029p1433 | Pituitary Clinical | ICEECE2012

Coexistence of macroprolactinaemia and hyperprolactinaemia in women with oligo-/amenorrhoea is associated with high risk of pituitary adenomas

Gasior-Perczak D. , Lewandowski K. , Kowalska A. , Lewinski A.

Background: The so called ‘big-big’ prolactin, also known as macroprolactin is formed by prolactin-immunoglobulin complexes, is considered to be biologically inactive, but may cause elevation of serum prolactin (Prl) concentrations measured by standard assays. In women presenting with oligo- and/or amenorrhoea the cause of menstrual irregularity needs to be explained even in the setting of concomitant macroprolactinaemia. We have therefore attempted to assess the pre...

ea0081rc6.5 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

Granin family peptides and INSM-1 (Insulinoma-associated protein 1) in the biochemical diagnosis of pheochromocytoma

Glinicki Piotr , Ostrowska Magdalena , Stelmachowska-Banas Maria , Papierska Lucyna , Szatko Alicja , Kowalski Konrad , Zgliczyński Wojciech

Introduction: Pheochromocytoma is a rare, usually benign tumor composed of neuroendocrine (chromaffin) cells of the adrenal medulla. It is the cause of secondary arterial hypertension. The biochemical diagnosis of a pheochromocytoma is based on the determination of concentration/excretion of catecholamine metabolites in blood or urine. The most sensitive biomarkers in the biochemical diagnosis of pheochromocytoma are plasma free methanephrines (metanephrine, normetanephrine an...

ea0090p35 | Calcium and Bone | ECE2023

Impact of a single oral bolus of 120,000 IU of cholecalciferol on vitamin D metabolites in the elderly: the results of randomized open study

Leszczynska Dorota , Szatko Alicja , Kowalski Konrad , Raczkiewicz Dorota , Ostrowska Magdalena , Misiorowski Waldemar , Zgliczyński Wojciech , Glinicki Piotr

Background: Vitamin D is a dietary micronutrient responsible for calcium and phosphorus metabolism and multiple extraskeletal actions. The assessment of vitamin D status is commonly based on measurement of 25(OH)D total concentration in serum. However, the usage of LC-MS/MS analytical technique allows to reliably assess a panel of vitamin D metabolites in serum or plasma, which may help to investigate the metabolic paths of vitamin D, especially in populations at risk of defic...

ea0081rc4.2 | Rapid Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

Macro-GH – a novel clinical entity causing a diagnostic challenge – a case report

Stelmachowska-Banas Maria , Ostrowska Magdalena , Goszczyński Tomasz , Kowalski Konrad , Korbonits Marta , Kapuścińska Renata , Zgliczyński Wojciech , Glinicki Piotr

Introduction: Hormone macromolecules are complexes of hormones with other compounds, most often with IgG immunoglobulin. They show variable immunoreactivity in immunochemical tests (IRMA, ELISA, CLIA, ECLIA) and usually have a weak biological effect. They can interfere with immunological assays of various hormones. Some known hormone macrocomplexes are: BB-PRL (24% - 34%), macro-TSH (0.6% - 1.2%) and very rare macromolecules of various hormones: calcitonin, PTH, insulin (singl...